Synthesis, structure and cytotoxic activity of diethyltin N-[(2-oxyphenyl)methylene]phenylalaninates
文献类型：期刊论文
| 作者 | Liu, Qingtao1; Zhang, Hao1; Zheng, Xiaoliang2; Wang, Wenqiang1; Tian, Laijin1 |
| 刊名 | APPLIED ORGANOMETALLIC CHEMISTRY
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 30期号:8页码:630-637 |
| 关键词 | organotin complex phenylalanine cytotoxic activity crystal structure |
| ISSN号 | 0268-2605 |
| DOI | 10.1002/aoc.3480 |
| 通讯作者 | Tian, Laijin(laijintian@163.com) |
| 英文摘要 | Four new diethyltin N-[(2-oxyphenyl)methylene]phenylalaninates, (CH3CH2)(2)Sn[2-O-3-X-5-YC6H2CHNCH(CH2Ph)COO] (X, Y = H, H, 1; H, Br, 2; H, OCH3, 3; Br, Br, 4), have been synthesized and characterized using elemental analysis and infrared and NMR (H-1, C-13 and Sn-119) spectra. The crystal structures of 1, 2, 3, 4 have been determined. Compounds 1 and 2 have a 12-membered macrocyclic structure with a trimeric [Sn3O6C3] core. Each tin atom is six-coordinated in distorted [SnC2NO3] octahedral geometry. Compound 3 is a centrosymmetric weak dimer in which the two tin centers are linked by two asymmetric SnOSn bridges involving the phenolic oxygen of the ligand and two SnO interactions from ether oxygen of the adjacent ligand. The coordination geometry of the tin atom can be described as a distorted pentagonal bipyramid with two ethyl groups in axial positions. Compound 4 is a novel binuclear tin complex, formed by the carboxylate of a ligand asymmetrically bridging two tin atoms, which contains a five-coordinated tin and a six-coordinated tin. Bioassay results have shown that the compounds have weak in vitro activity against two human tumor cell lines, A549 and CoLo205. Copyright (c) 2016 John Wiley & Sons, Ltd. |
| WOS关键词 | ALPHA-AMINO-ACID ; DIORGANOTIN(IV) COMPLEXES ; CRYSTAL-STRUCTURES ; X-RAY ; ORGANOTIN(IV) COMPLEXES ; BIOLOGICAL-ACTIVITY ; SCHIFF-BASES ; MOIETIES ; NMR |
| 资助项目 | Shandong Provincial Natural Science Foundation, China[ZR2013BM007] ; National Natural Science Foundation of China[21302110] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000379969700004 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291819]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Tian, Laijin |
| 作者单位 | 1.Qufu Normal Univ, Key Lab Nat Prod & Pharmaceut Intermediates, Qufu 273165, Peoples R China 2.Zhejiang Acad Med Sci, Inst Mat Med, Hangzhou 310013, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qingtao,Zhang, Hao,Zheng, Xiaoliang,et al. Synthesis, structure and cytotoxic activity of diethyltin N-[(2-oxyphenyl)methylene]phenylalaninates[J]. APPLIED ORGANOMETALLIC CHEMISTRY,2016,30(8):630-637. |
| APA | Liu, Qingtao,Zhang, Hao,Zheng, Xiaoliang,Wang, Wenqiang,&Tian, Laijin.(2016).Synthesis, structure and cytotoxic activity of diethyltin N-[(2-oxyphenyl)methylene]phenylalaninates.APPLIED ORGANOMETALLIC CHEMISTRY,30(8),630-637. |
| MLA | Liu, Qingtao,et al."Synthesis, structure and cytotoxic activity of diethyltin N-[(2-oxyphenyl)methylene]phenylalaninates".APPLIED ORGANOMETALLIC CHEMISTRY 30.8(2016):630-637. |
入库方式： OAI收割
来源：上海药物研究所
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