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Effects of Paeonol and Gastroretention Tablets of Paeonol on Experimental Gastric Ulcers and Intestinal Flora in Rats

文献类型：期刊论文

作者Guo, Yilin2,3; Du, Yaoyao3; Xie, Lu4; Pu, Yiqiong2; Yuan, Jianlong5; Wang, Zhicheng1; Zhang, Tong2,3; Wang, Bing3,6
刊名INFLAMMATION
出版日期2020-07-09
页码13
关键词gastric ulcer paeonol gastroretention tablets of paeonol pyloric ligation acetic acid intestinal flora
ISSN号0360-3997
DOI10.1007/s10753-020-01285-y
通讯作者Wang, Zhicheng() ; Zhang, Tong(zhangtdmj@hotmail.com)
英文摘要Paeonol, a major ingredient isolated fromMoutan Cort,has various pharmacological effects. Our previous studies have shown that paeonol can exert antioxidant and anti-inflammatory therapeutic effects on ethanol-induced experimental gastric ulcer (GU). Therefore, in this study, we designed two GU models in rats induced by pyloric ligation (PL) and acetic acid and evaluated the protective effects of paeonol and gastroretention tablets of paeonol (GRT-Ps; 24, 48, and 96 mg/kg) on GU in rats and the effect of paeonol (48 mg/kg) on the intestinal flora.In vivoexperiments showed that paeonol or GRT-Ps remarkably reduced gastric mucosal damage in a dose-dependent manner in the different types of models and improved the superoxide dismutase (SOD) activity and the malondialdehyde (MDA) content. And in fact, the sustained-release effect of GRT-Ps is more conducive to the improvement of GU compared with the rapid clearance of free drugs. In the PL-induced model, gastric secretion parameters, that is, pH and total acid, showed significant differences compared with the model group. In addition, paeonol treatment can improve the richness and diversity of the intestinal flora and increase the amount of beneficial bacteria, such asLactobacillus. Paeonol and its stable sustained-release tablet GRT-Ps can promote ulcer healing by inhibiting oxidative stress and regulating the intestinal flora. This study can provide basis for the clinical treatment of GU with paeonol. Graphical Abstract
WOS关键词GASTROPROTECTIVE ACTIVITY ; PROTECTIVE ACTIVITY ; OXIDATIVE STRESS ; IN-VIVO ; ANTIOXIDANT ; PATHOGENESIS ; EXTRACT ; INJURY ; LEAVES ; MICE
资助项目Shanghai Committee of Science and Technology[17401902300] ; Shanghai Committee of Science and Technology[18401931400] ; Program of Shanghai Academic/Technology Research Leader[18XD1403700] ; National Science and Technology Major Project[2019ZX09201004-002] ; Key project of Shanghai 3year plan[ZY (2018-2020)-CCCX-2001-04]
WOS研究方向Cell Biology ; Immunology
语种英语
WOS记录号WOS:000546519700002
出版者SPRINGER/PLENUM PUBLISHERS
源URL[http://119.78.100.183/handle/2S10ELR8/291885]  
专题中国科学院上海药物研究所
通讯作者Wang, Zhicheng; Zhang, Tong
作者单位1.Fudan Univ, Dept Lab Med, Huashan Hosp, 12 Wulumuqi Middle Rd, Shanghai 200040, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, 1200 Cailun Rd, Shanghai 201203, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, 185 Puan Rd, Shanghai 200021, Peoples R China
5.Fujian Med Prod Adm, 156 Dongpu Rd, Fuzhou 350013, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Yilin,Du, Yaoyao,Xie, Lu,et al. Effects of Paeonol and Gastroretention Tablets of Paeonol on Experimental Gastric Ulcers and Intestinal Flora in Rats[J]. INFLAMMATION,2020:13.
APA Guo, Yilin.,Du, Yaoyao.,Xie, Lu.,Pu, Yiqiong.,Yuan, Jianlong.,...&Wang, Bing.(2020).Effects of Paeonol and Gastroretention Tablets of Paeonol on Experimental Gastric Ulcers and Intestinal Flora in Rats.INFLAMMATION,13.
MLA Guo, Yilin,et al."Effects of Paeonol and Gastroretention Tablets of Paeonol on Experimental Gastric Ulcers and Intestinal Flora in Rats".INFLAMMATION (2020):13.

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来源：上海药物研究所

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