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Synthesis of oleandrin derivatives and their cytotoxic activity

文献类型：期刊论文

作者Zhang, Yanzhi2; Chen, Xubing2; Zhou, Yang1,3; Hou, Jinjun1,3; Long, Huali1,3; Zhang, Zijia1,3; Lei, Min1,3; Wu, Wanying1,3
刊名STEROIDS
出版日期2020-07-01
卷号159页码:7
关键词Cardiac glycosides Oleandrin (OL) Natural product OL-4 '-yl ester Cytotoxicity
ISSN号0039-128X
DOI10.1016/j.steroids.2020.108650
通讯作者Lei, Min(mlei@simm.ac.cn) ; Wu, Wanying(wanyingwu@simm.ac.cn)
英文摘要A series of oleandrin-4'-yl ester derivatives were designed, synthesized, and evaluated for their proliferation inhibition activities against tumor cell lines. Cytotoxicity data revealed that the C4' moiety had an important influence on cytotoxic activity. Several compounds that we designed and synthesized exhibit significant in vitro antiproliferative activity against the tested tumor cell lines. Among the derivatives of OL, 4b-HCl not only had good anti-tumor activity but also had good water solubility. Furthermore, 4b-HCl can significantly inhibit tumor growth by 96.4% at a dose of 6 mg/kg/d by ip.
WOS关键词CARDENOLIDE GLYCOSIDES ; CARDIAC-GLYCOSIDES ; BUFADIENOLIDES
资助项目Special Fund for Strategic Pilot Technology Chinese Academy of Sciences[XDA12020379] ; National Natural Science Foundation of China[81973455] ; National Key R&D Program of China[2018YFC1707900]
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种英语
WOS记录号WOS:000545320700009
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/291888]  
专题中国科学院上海药物研究所
通讯作者Lei, Min; Wu, Wanying
作者单位1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China
2.Dali Univ, Coll Pharm, Dali 671000, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yanzhi,Chen, Xubing,Zhou, Yang,et al. Synthesis of oleandrin derivatives and their cytotoxic activity[J]. STEROIDS,2020,159:7.
APA Zhang, Yanzhi.,Chen, Xubing.,Zhou, Yang.,Hou, Jinjun.,Long, Huali.,...&Wu, Wanying.(2020).Synthesis of oleandrin derivatives and their cytotoxic activity.STEROIDS,159,7.
MLA Zhang, Yanzhi,et al."Synthesis of oleandrin derivatives and their cytotoxic activity".STEROIDS 159(2020):7.

入库方式： OAI收割

来源：上海药物研究所

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