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MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy

文献类型：期刊论文

作者Wei, Yan2; Song, Sha3; Duan, Nianxiu3; Wang, Feng1; Wang, Yuxi2; Yang, Yiwei2; Peng, Chengyuan4; Li, Junjun2; Nie, Di2; Zhang, Xinxin2
刊名ADVANCED SCIENCE
出版日期2020-07-10
页码14
关键词membrane type 1-matrix metalloproteinase-activated cilengitide pancreatic cancer smart liposomes vascular promotion
DOI10.1002/advs.201902746
通讯作者Gan, Yong(ygan@simm.ac.cn)
英文摘要Promoting tumor angiogenesis effectively and specifically to resolve tumor-associated hypoperfusion holds promise for improving pancreatic cancer therapy. Herein, a doxorubicin (DOX) loaded smart liposome, MC-T-DOX, is constructed, that carries appropriately low-density cilengitide, an alpha v beta 3 integrin-specific Arg-Gly-Asp (RGD)-mimetic cyclic peptide, via a membrane type 1-matrix metalloproteinase (MT1-MMP) cleavable peptide. After being administered systemically in a hypoperfused pancreatic cancer mouse model at a low dose of cilengitide, the proangiogenic activity of MC-T-DOX is specifically "turned on" in tumor vessels through cleavage by MT1-MMP on tumor endothelial cells to release cilengitide. This locally released cilengitide increases tumor blood perfusion, thereby improving the accumulation and distribution of MC-T-DOX in the tumor site. The loaded-DOX then displays enhanced penetration and increased cellular uptake upon heat-triggered release from MC-T-DOX in the tumor interstitium, contributing to the improved tumor therapy efficacy. Therefore, the strategy of combining the modulation of tumor vascular promotion with smart nanodrug delivery represents a promising approach to improving drug delivery and therapeutic efficacy in a wide range of hypoperfused tumors.
WOS关键词INTEGRIN ALPHA(V)BETA(3) ; ANGIOGENESIS ; EFFICACY ; INHIBITION ; STRATEGIES ; BARRIERS ; DESIGN ; GROWTH
资助项目National Natural Science Foundation of China[81703010] ; National Natural Science Foundation of China[81872428] ; China Postdoctoral Science Foundation[2016M600342] ; National Key Research and Development Program of China[NBHY-2017-J1-3] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDA15014200]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000546679400001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/291892]  
专题新药研究国家重点实验室
通讯作者Gan, Yong
作者单位1.Shanghai Hansoh Biomed R&D Inc, Dept Med Chem, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Nanchang Univ, Coll Med, Dept Pharm, Nanchang 330066, Jiangxi, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Yan,Song, Sha,Duan, Nianxiu,et al. MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy[J]. ADVANCED SCIENCE,2020:14.
APA Wei, Yan.,Song, Sha.,Duan, Nianxiu.,Wang, Feng.,Wang, Yuxi.,...&Gan, Yong.(2020).MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy.ADVANCED SCIENCE,14.
MLA Wei, Yan,et al."MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy".ADVANCED SCIENCE (2020):14.

入库方式： OAI收割

来源：上海药物研究所

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