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A new 5 alpha,8 alpha-epidioxysterol with immunosuppressive activity from the South China Sea soft coralSinulariasp.

文献类型：期刊论文

作者Yang, Min1,2; Liang, Lin-Fu2,4; Li, Heng1,2; Tang, Wei1,2; Guo, Yue-Wei1,2,3
刊名NATURAL PRODUCT RESEARCH
出版日期2020-07-02
卷号34期号:13页码:1814-1819
关键词Immunosuppressive activity Soft coral Sinulariasp 5 alpha 8 alpha-Epidioxysterol Yalongsterol A
ISSN号1478-6419
DOI10.1080/14786419.2018.1561683
通讯作者Tang, Wei(tangwei@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要A new 5 alpha,8 alpha-epidioxysterol, namely yalongsterol A (1), along with two known related steroids 5 alpha,8 alpha-epidioxy-24-methyl-cholesta-6,24(28)-dien-3 beta-ol (2) and (22E,24S)-5 alpha,8 alpha-epidioxy-24-methyl-cholesta-6,22-dien-3 beta-ol (3), were isolated from the South China Sea soft coralSinulariasp. Their structures were established by extensive spectroscopic analyses and comparisons of the spectral data with those reported in the literature. In bioassay, compounds1-3showed moderate immunosuppressive activities against T and/or B lymphocyte cells with IC(50)values ranging from 19.30 to 59.49 mu M, and low cytotoxicity on murine splenocytes with CC(50)values ranging from 40.88 to 62.29 mu M.
WOS关键词POLYHYDROXYLATED STEROIDS ; SINULARIA ; METABOLITES ; SPONGE
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000544807500002
出版者TAYLOR & FRANCIS LTD
源URL[http://119.78.100.183/handle/2S10ELR8/291948]  
专题新药研究国家重点实验室
通讯作者Tang, Wei; Guo, Yue-Wei
作者单位1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
4.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Min,Liang, Lin-Fu,Li, Heng,et al. A new 5 alpha,8 alpha-epidioxysterol with immunosuppressive activity from the South China Sea soft coralSinulariasp.[J]. NATURAL PRODUCT RESEARCH,2020,34(13):1814-1819.
APA Yang, Min,Liang, Lin-Fu,Li, Heng,Tang, Wei,&Guo, Yue-Wei.(2020).A new 5 alpha,8 alpha-epidioxysterol with immunosuppressive activity from the South China Sea soft coralSinulariasp..NATURAL PRODUCT RESEARCH,34(13),1814-1819.
MLA Yang, Min,et al."A new 5 alpha,8 alpha-epidioxysterol with immunosuppressive activity from the South China Sea soft coralSinulariasp.".NATURAL PRODUCT RESEARCH 34.13(2020):1814-1819.

入库方式： OAI收割

来源：上海药物研究所

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