Limonoids from Cipadessa baccifera
文献类型：期刊论文
| 作者 | Yu, Jin-Hai2; Zhang, Hua2; Zhou, Bin2; Zimbres, Flavia M.3,4; Dalal, Seema1; Liu, Qun-Fang2 ; Cassera, Maria B.3,4; Yue, Jian-Min2
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2020-06-26 |
| 卷号 | 83期号:6页码:1751-1765 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.9b00666 |
| 通讯作者 | Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Eighteen new limonoids, including eight methyl angolensates (1-8) and 10 cipadesins (9-18), were isolated from the leaves of Cipadessa baccifera. Their structures were characterized by means of spectroscopic data analyses, single-crystal X-ray diffraction, and quantum chemistry computational methods. The C-6 configurations in those compounds possessing a C-6 hydroxy group were all assigned as S regardless of the magnitude of J(5,6), and the C-2' configuration in those bearing a 2-methylbutyryl residue was defined by single-crystal X-ray diffraction and NMR data. Compounds 1, 5, 6, 7, 11, and 12 showed moderate antimalarial activities with IC50 values ranging from 12 to 28 mu M. |
| WOS关键词 | A-D ; TETRANORTRITERPENOIDS ; SKELETONS ; CHEMISTRY ; SEEDS |
| 资助项目 | National Natural Science Foundation of China[81872758] ; National Natural Science Foundation of China[21532007] ; Drug Innovation Major Project of China[2018ZX09711001-001-005] ; Biological Resources Programme, CAS of China[KFJ-BRP-008] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000545691700003 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291958]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Virginia Polytech Inst & State Univ, Dept Biochem, MC 0308, Blacksburg, VA 24061 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA 4.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Athens, GA 30602 USA |
| 推荐引用方式 GB/T 7714 | Yu, Jin-Hai,Zhang, Hua,Zhou, Bin,et al. Limonoids from Cipadessa baccifera[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(6):1751-1765. |
| APA | Yu, Jin-Hai.,Zhang, Hua.,Zhou, Bin.,Zimbres, Flavia M..,Dalal, Seema.,...&Yue, Jian-Min.(2020).Limonoids from Cipadessa baccifera.JOURNAL OF NATURAL PRODUCTS,83(6),1751-1765. |
| MLA | Yu, Jin-Hai,et al."Limonoids from Cipadessa baccifera".JOURNAL OF NATURAL PRODUCTS 83.6(2020):1751-1765. |
入库方式： OAI收割
来源：上海药物研究所
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