Efficient incorporation and protection of lansoprazole in cyclodextrin metal-organic frameworks
文献类型：期刊论文
| 作者 | Li, Xue5; Porcino, Marianna6; Martineau-Corcos, Charlotte6,7,8; Guo, Tao9; Xiong, Ting10; Zhu, Weifeng10; Patriarche, Gilles1; Pechoux, Christine2; Perronne, Barbara4; Hassan, Alia4 |
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2020-07-30 |
| 卷号 | 585页码:11 |
| 关键词 | Cyclodextrin Metal-organic frameworks Lansoprazole Inclusion complex Drug stability |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2020.119442 |
| 通讯作者 | Gref, Ruxandra(ruxandra.gref@universite-paris-saclay.fr) |
| 英文摘要 | Lansoprazole (LPZ) is an acid pump inhibitor, which readily degrades upon acidic or basic conditions and under heating. We investigated here LPZ stability upon incorporation in particles made of cyclodextrin metal-organic frameworks (CD-MOFs). LPZ loaded CD-MOFs were successfully synthesized, reaching high LPZ payloads of 23.2 +/- 2.1 wt%, which correspond to a molar ratio of 1:1 between LPZ and gamma-CD. The homogeneity of LPZ loaded CD-MOFs in terms of component distribution was confirmed by elemental mapping by STEM-EDX. Both CTAB, the surfactant used in the CD-MOFs synthesis, and LPZ compete for their inclusion in the CD cavities. CTAB allowed obtaining regular cubic particles of around 5 mu m with 15 wt% residual CTAB amounts. When LPZ was incorporated, the residual CTAB amount was less than 0.1 wt%, suggesting a higher affinity of LPZ for the CDs than CTAB. These findings were confirmed by molecular simulations. Vibrational circular dichroism studies confirmed the LPZ incorporation inside the CDs. Solid-state NMR showed that LPZ was located in the CDs and that it remained intact even after three years storage. Remarkably, the CD-MOFs matrix protected the drug upon thermal decomposition. This study highlights the interest of CD-MOFs for the incorporation and protection of LPZ. |
| WOS关键词 | VIBRATIONAL CIRCULAR-DICHROISM ; GAMMA-CYCLODEXTRIN ; BETA-CYCLODEXTRIN ; NMR ; STABILITY ; INCLUSION ; OMEPRAZOLE ; COMPLEXES ; FORMULATIONS ; SPECTROSCOPY |
| 资助项目 | French National Research Agency[ANR-10-LABX-0035] ; French National Research Agency[ANR-14-CE08-0017] ; National Science and Technology Major Projects for Major New Drugs Innovation and Development[2018ZX09721002-009] ; IRRMN-THC Fr3050 CNRS ; MIMA2-MET platform ; Ile-de-France DIM RESPORE ; Region Centre-Val de Loire |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000547812700006 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291970]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Gref, Ruxandra |
| 作者单位 | 1.Univ Paris Saclay, Ctr Nanosci & Nanotechnol, CNRS, F-91120 Palaiseau, France 2.Univ Paris Saclay, GABI, AgroParisTech, INRAE, F-78350 Jouy En Josas, France 3.PerkinElmer, 16 Ave Quebec, F-91140 Villebon Sur Yvette, France 4.Bruker Biospin Corp, CH-8117 Fallanden, Switzerland 5.Univ Paris Saclay, Inst Sci Mol Orsay, CNRS, F-91405 Orsay, France 6.Univ Orleans, CEMHTI UPR CNRS 3079, F-45071 Orleans, France 7.Univ Versailles St Quentin en Yvelines, Univ Paris Saclay, ILV UMR CNRS 8180, F-78035 Versailles, France 8.Inst Univ France IUF, F-75005 Paris, France 9.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China 10.Jiangxi Univ Tradit Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xue,Porcino, Marianna,Martineau-Corcos, Charlotte,et al. Efficient incorporation and protection of lansoprazole in cyclodextrin metal-organic frameworks[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2020,585:11. |
| APA | Li, Xue.,Porcino, Marianna.,Martineau-Corcos, Charlotte.,Guo, Tao.,Xiong, Ting.,...&Gref, Ruxandra.(2020).Efficient incorporation and protection of lansoprazole in cyclodextrin metal-organic frameworks.INTERNATIONAL JOURNAL OF PHARMACEUTICS,585,11. |
| MLA | Li, Xue,et al."Efficient incorporation and protection of lansoprazole in cyclodextrin metal-organic frameworks".INTERNATIONAL JOURNAL OF PHARMACEUTICS 585(2020):11. |
入库方式： OAI收割
来源：上海药物研究所
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