A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate molluskOnchidiumsp
文献类型：期刊论文
| 作者 | Li, Song-Wei2,3,4; Cui, Wan-Xiang1,2,4; Huan, Xia-Juan2; Gavagnin, Margherita5; Mollo, Ernesto5; Miao, Ze-Hong2; Yao, Li-Gong2,4; Li, Xu-Wen2,4 ; Guo, Yue-Wei2,4
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| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2020-07-17 |
| 卷号 | 34期号:14页码:1971-1976 |
| 关键词 | bis-gamma-pyrone polypropionate X-ray diffraction absolute configuration cytotoxicity marine natural product marine pulmonated mollusk |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2019.1569010 |
| 通讯作者 | Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | A new bis-gamma-pyrone polypropionate, 4,16-di-epi-onchidiol (1), along with three known related compounds (2-4) were isolated from the marine pulmonate molluskOnchidiumsp. The structure of compound1was elucidated by extensive spectroscopic analysis and by comparison the NMR data with its stereoisomers2-4, whereas its absolute configuration was determined by the combination of X-ray diffraction analysis and TDDFT-ECD calculation. In bioassay, the isolated compounds exhibited broad cytotoxicity against several cancer cell lines with IC(50)values ranging from 24.6 to 88.5 mu M. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000547162000003 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291977]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Xu-Wen; Guo, Yue-Wei |
| 作者单位 | 1.Binzhou Med Univ, Sch Pharm, Yantai, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Nanjing Univ Tradit Chinese Med, Nanjing, Peoples R China 4.Open Studio Druggabil Res Marine Nat Prod, Pilot Natl Lab Marine Sci & Technol Qingdao, Qingdao, Peoples R China 5.Consiglio Nazl Ric CNR, Ist Chim Biomol ICB, Naples, Italy |
| 推荐引用方式 GB/T 7714 | Li, Song-Wei,Cui, Wan-Xiang,Huan, Xia-Juan,et al. A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate molluskOnchidiumsp[J]. NATURAL PRODUCT RESEARCH,2020,34(14):1971-1976. |
| APA | Li, Song-Wei.,Cui, Wan-Xiang.,Huan, Xia-Juan.,Gavagnin, Margherita.,Mollo, Ernesto.,...&Guo, Yue-Wei.(2020).A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate molluskOnchidiumsp.NATURAL PRODUCT RESEARCH,34(14),1971-1976. |
| MLA | Li, Song-Wei,et al."A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate molluskOnchidiumsp".NATURAL PRODUCT RESEARCH 34.14(2020):1971-1976. |
入库方式： OAI收割
来源：上海药物研究所
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