Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma
文献类型：期刊论文
| 作者 | Feng, Qilin2; Yao, Qingchun1; Li, Bo3; Xie, Yongsheng2; Zhang, Hui2; Xu, Zhijian3 ; Lu, Kang2; Hu, Ke2; Cheng, Yao2; Shi, Bingqing2
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| 刊名 | JOURNAL OF CANCER
 |
| 出版日期 | 2020 |
| 卷号 | 11期号:16页码:4907-4916 |
| 关键词 | DCZ0801 multiple myeloma apoptosis cell cycle glycolysis |
| ISSN号 | 1837-9664 |
| DOI | 10.7150/jca.45146 |
| 通讯作者 | You, Shanxi(Js_ysx@sina.com) ; Shi, Jumei(shijumei@tongji.edu.cn) ; Zhu, Weiliang(wlzhu@simm.ac.cn) |
| 英文摘要 | Multiple myeloma (MM) is a highly invasive and incurable plasma cell malignant disease with frequent recurrence. DCZ0801 is a natural compound synthesized from osalmide and pterostilbene and has few adverse effects. Here, we aimed to observe the therapeutic effects of DCZ0801 on myeloma cells and clarify the specific molecular mechanism underlying its anti-tumor activity. The Cell Counting Kit-8 assay, apoptosis detection, cell cycle analysis, western blot analysis, and tumor xenograft models were used to determine the effect of DCZ0801 treatment both in vivo and in vitro. We revealed that DCZ0801 treatment suppressed MM cell survival by inducing apoptosis and blocking the cell cycle at S phase. Deranged glycolysis and downregulated Akt/mTOR pathway may also be responsible for cell proliferation inhibition. Moreover, DCZ0801 treatment could remarkably reduce the tumor size in the xenograft mouse model. Therefore these findings indicate that DCZ0801 can be used as a novel therapeutic drug for patients suffering from multiple myeloma. |
| WOS关键词 | PYRUVATE-KINASE ; CANCER ; GROWTH ; M2 ; METABOLISM ; DYSREGULATION ; INHIBITION ; DIAGNOSIS ; PROMOTES ; PKM2 |
| 资助项目 | National Natural Science Foundation of China[81670194] ; National Natural Science Foundation of China[81870158] ; National Natural Science Foundation of China[81900212] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000549095900002 |
| 出版者 | IVYSPRING INT PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292056]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | You, Shanxi; Shi, Jumei; Zhu, Weiliang |
| 作者单位 | 1.Taizhou Fourth Peoples Hosp, Dept Oncol, Taizhou 225300, Jiangsu, Peoples R China 2.Tongji Univ, Shanghai Peoples Hosp 10, Dept Hematol, Sch Med, Shanghai 200072, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Qilin,Yao, Qingchun,Li, Bo,et al. Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma[J]. JOURNAL OF CANCER,2020,11(16):4907-4916. |
| APA | Feng, Qilin.,Yao, Qingchun.,Li, Bo.,Xie, Yongsheng.,Zhang, Hui.,...&Zhu, Weiliang.(2020).Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma.JOURNAL OF CANCER,11(16),4907-4916. |
| MLA | Feng, Qilin,et al."Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma".JOURNAL OF CANCER 11.16(2020):4907-4916. |
入库方式： OAI收割
来源：上海药物研究所
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