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  2. 上海药物研究所
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  4. 新药研究国家重点实验室
Further polyoxygenated cembranoids from South China Sea soft coral Sarcophyton ehrenbergi

文献类型：期刊论文

作者Li, Geng3,4; Li, Heng2,3; Tang, Wei2,3; Yao, Li-Gong4; Liang, Lin-Fu1; Guo, Yue-Wei1,3,4
刊名BIOORGANIC CHEMISTRY
出版日期2020-08-01
卷号101页码:9
关键词Soft coral Sarcophyton ehrenbergi Cembrane-type diterpenoids Modified Mosher's method ECD calculation TNF-alpha inhibitory activity
ISSN号0045-2068
DOI10.1016/j.bioorg.2020.103993
通讯作者Liang, Lin-Fu(lianglinfu@aliyun.com) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Eleven new cembrane diterpenes, namely, sarcoehrenins A-J (1-9, 11) and (2S,11S,12S)-isosarcophytoxide (10), along with six known compounds, gibberosene B (12), (13S)-cembra-1,3,7,11-tetraen-13-ol (13), (+)-sarcophtol (14), cembrene-C (15), (1R,4R,2E,7E,11E)-cembra-2,7,11-trien-4-ol (16) and (1S,4R,2E,7E,11E)cembratrien-4-ol (17) were isolated from the soft coral Sarcophyton ehrenbergi collected from Weizhou Island, Beibu Gulf, South China Sea. The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. The absolute configuration of compound 2 was established by the modified Mosher's method in association with TDDFT ECD calculation, while the absolute configuration of compound 3 was assigned by TDDFT ECD approach. In in vitro bioassays, compounds 13 and 17 showed potent TNF-alpha inhibitory activities being similar to that of positive control dexamethasone. A preliminary structural-activity relationship was also described.
WOS关键词ENANTIOSELECTIVE TOTAL-SYNTHESIS ; NATURAL-PRODUCTS ; DITERPENES ; METABOLITES ; CHEMISTRY
资助项目Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; Natural Science Foundation of China[41876194] ; National Key Research and Development Program of China[2018YFC0310903] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000552622000008
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/292127]  
专题新药研究国家重点实验室
通讯作者Liang, Lin-Fu; Guo, Yue-Wei
作者单位1.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Li, Geng,Li, Heng,Tang, Wei,et al. Further polyoxygenated cembranoids from South China Sea soft coral Sarcophyton ehrenbergi[J]. BIOORGANIC CHEMISTRY,2020,101:9.
APA Li, Geng,Li, Heng,Tang, Wei,Yao, Li-Gong,Liang, Lin-Fu,&Guo, Yue-Wei.(2020).Further polyoxygenated cembranoids from South China Sea soft coral Sarcophyton ehrenbergi.BIOORGANIC CHEMISTRY,101,9.
MLA Li, Geng,et al."Further polyoxygenated cembranoids from South China Sea soft coral Sarcophyton ehrenbergi".BIOORGANIC CHEMISTRY 101(2020):9.

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来源：上海药物研究所

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