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Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice

文献类型：期刊论文

作者Yu, Yan-yan1,2; Cui, Shi-chao1; Zheng, Tian-nan1,2; Ma, Hai-jian1; Xie, Zhi-fu1; Jiang, Hao-wen1; Li, Yu-feng1,2; Zhu, Ke-xin1,2; Huang, Cheng-gang1; Li, Jia1
刊名ACTA PHARMACOLOGICA SINICA
出版日期2020-07-22
页码10
关键词insulin resistance sarsasapogenin adipose tissue inflammation macrophage-adipocyte crosstalk IKK/NF-kappa B JNK
ISSN号1671-4083
DOI10.1038/s41401-020-0427-1
通讯作者Li, Jia(jli@simm.ac.cn) ; Li, Jing-ya(jyli@simm.ac.cn)
英文摘要Insulin resistance is a major cause of type 2 diabetes and metabolic syndrome. Macrophage infiltration into obese adipose tissue promotes inflammatory responses that contribute to the pathogenesis of insulin resistance. Suppression of adipose tissue inflammatory responses is postulated to increase insulin sensitivity in obese patients and animals. Sarsasapogenin (ZGY) is one of the metabolites of timosaponin AIII in the gut, which has been shown to exert anti-inflammatory action. In this study, we investigated the effects of ZGY treatment on obesity-induced insulin resistance in mice. We showed that pretreatment with ZGY (80 mg.kg(-1).d(-1), ig, for 18 days) significantly inhibited acute adipose tissue inflammatory responses in LPS-treated mice. In high-fat diet (HFD)-fed obese mice, oral administration of ZGY (80 mg.kg(-1).d(-1), for 6 weeks) ameliorated insulin resistance and alleviated inflammation in adipose tissues by reducing the infiltration of macrophages. Furthermore, we demonstrated that ZGY not only directly inhibited inflammatory responses in macrophages and adipocytes, but also interrupts the crosstalk between macrophages and adipocytes in vitro, improving adipocyte insulin resistance. The insulin-sensitizing and anti-inflammatory effects of ZGY may result from inactivation of the IKK/NF-kappa B and JNK inflammatory signaling pathways in adipocytes. Collectively, our findings suggest that ZGY ameliorates insulin resistance and alleviates the adipose inflammatory state in HFD mice, suggesting that ZGY may be a potential agent for the treatment of insulin resistance and obesity-related metabolic diseases.
WOS关键词PARACRINE LOOP ; KAPPA-B ; OBESITY ; MACROPHAGES ; ADIPOCYTES ; ACTIVATION ; SENSITIVITY ; MECHANISMS ; RESPONSES ; KINASE
资助项目Ministry of Science and Technology[2018ZX09711002-018] ; Ministry of Science and Technology[2016YFC1305505] ; National Natural Science Foundation of China[81673493]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000551409300002
出版者NATURE PUBLISHING GROUP
源URL[http://119.78.100.183/handle/2S10ELR8/292132]  
专题新药研究国家重点实验室
通讯作者Li, Jia; Li, Jing-ya
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Yan-yan,Cui, Shi-chao,Zheng, Tian-nan,et al. Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice[J]. ACTA PHARMACOLOGICA SINICA,2020:10.
APA Yu, Yan-yan.,Cui, Shi-chao.,Zheng, Tian-nan.,Ma, Hai-jian.,Xie, Zhi-fu.,...&Li, Jing-ya.(2020).Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice.ACTA PHARMACOLOGICA SINICA,10.
MLA Yu, Yan-yan,et al."Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice".ACTA PHARMACOLOGICA SINICA (2020):10.

入库方式： OAI收割

来源：上海药物研究所

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