Nitric oxide inhibitory iridoids as potential anti-inflammatory agents from Valeriana jatamansi
文献类型：期刊论文
| 作者 | Wang, Huimei3,4; Song, Ziteng3,4; Xing, Honghong3,4; Shi, Zhaoyu3,4; Wu, Peng3,4; Zhang, Jie1; Tuerhong, Muhetaer5; Xu, Jing3,4; Guo, Yuanqiang2,3,4 |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2020-08-01 |
| 卷号 | 101页码:9 |
| 关键词 | Iridoids NO inhibitory activities Valeriana jatamansi Inflammation Molecular docking |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2020.103974 |
| 通讯作者 | Xu, Jing(xujing611@nankai.edu.cn) ; Guo, Yuanqiang(victgyq@nankai.edu.cn) |
| 英文摘要 | Five new iridoids, jatadomins A-E (1-5), together with six known analogues (6-11) and one known sesqui-terpenoid (12), were isolated from the roots of Valeriana jatamansi Jones. Their structures were determined by analysis of their NMR, HRESIMS, and electronic circular dichroism calculations (ECD) data. The biological evaluation revealed that compounds 1-6 had anti-inflammatory activities by inhibiting nitric oxide (NO) release in LPS-induced murine microglial BV-2 cells, with IC50 values of 24.4, 9.2, 21.2, 25.9, 30.6, and 0.4 mu M, re-spectively. Further molecular docking studies revealed a potential mechanism for NO inhibition by the bioactive compounds. |
| WOS关键词 | ANTI-NEUROINFLAMMATORY AGENTS ; ANTIOXIDANT ACTIVITY ; ACYLATED IRIDOIDS ; CELL-DEATH ; ROOTS ; SESQUITERPENOIDS ; RHIZOMES ; PHYTOCHEMICALS ; CYTOTOXICITY ; LIGNANS |
| 资助项目 | National Key Research and Development Program of China[2018YFA0507204] ; National Natural Science Foundation of China[U1703107] ; National Natural Science Foundation of China[U1801288] ; Hundred Young Academic Leaders Program of Nankai University ; Natural Science Foundation of Tianjin[19JCYBJC28100] ; State Key Laboratory of Drug Research[SIMM2004KF-13] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000552636200005 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292173]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Jing; Guo, Yuanqiang |
| 作者单位 | 1.Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nankai Univ, Coll Pharm, Tianjin Key Lab Mol Drug Res, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China 4.Nankai Univ, Drug Discovery Ctr Infect Dis, Tianjin 300350, Peoples R China 5.Kashgar Univ, Coll Chem & Environm Sci, Lab Xinjiang Nat Med & Edible Plant Resources Che, Kashgar 844000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Huimei,Song, Ziteng,Xing, Honghong,et al. Nitric oxide inhibitory iridoids as potential anti-inflammatory agents from Valeriana jatamansi[J]. BIOORGANIC CHEMISTRY,2020,101:9. |
| APA | Wang, Huimei.,Song, Ziteng.,Xing, Honghong.,Shi, Zhaoyu.,Wu, Peng.,...&Guo, Yuanqiang.(2020).Nitric oxide inhibitory iridoids as potential anti-inflammatory agents from Valeriana jatamansi.BIOORGANIC CHEMISTRY,101,9. |
| MLA | Wang, Huimei,et al."Nitric oxide inhibitory iridoids as potential anti-inflammatory agents from Valeriana jatamansi".BIOORGANIC CHEMISTRY 101(2020):9. |
入库方式： OAI收割
来源：上海药物研究所
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