Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo
文献类型：期刊论文
| 作者 | Wu, Peng2,3; Song, Ziteng2,3; Wang, Xuelian2,3; Li, Ying2,3; Li, Yuhao4; Cui, Jianlin4; Tuerhong, Muhetaer5; Jin, Da-Qing4; Abudukeremu, Munira5; Lee, Dongho6 |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2020-08-01 |
| 卷号 | 101页码:10 |
| 关键词 | Euphane triterpenoids Anti-inflammatory properties Molecular docking Zebrafish model Lantana camara |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2020.104004 |
| 通讯作者 | Xu, Jing(xujing611@nankai.edu.cn) ; Guo, Yuanqiang(victgyq@nankai.edu.cn) |
| 英文摘要 | Bioactive natural products play an important role in the research and development of new drugs. In our search for bioactive natural substances as potential lead compounds for inflammation, four new (1-4) and six known (6-10) triterpenoids were acquired from Lantana camara. Using NMR and MS techniques and electronic circular dichroism (ECD) calculations, these isolates were characterized and the new compounds (1-4) were found to be euphane-type triterpenoids. The in vitro anti-inflammatory effects of all the isolates were evaluated and the more bioactive compounds were selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments, as well as the in vivo anti-inflammatory evaluation using a zebrafish model. |
| WOS关键词 | ANTI-NEUROINFLAMMATORY AGENTS ; PENTACYCLIC TRITERPENOIDS ; AERIAL PARTS ; INHIBITORY-ACTIVITIES ; NATURAL-PRODUCTS ; ACID ; CONSTITUENTS ; INFLAMMATION ; LIMONOIDS ; LEAVES |
| 资助项目 | National Natural Science Foundation of China[U1703107] ; National Natural Science Foundation of China[U1801288] ; Natural Science Foundation of Tianjin, China[19JCYBJC28100] ; Hundred Young Academic Leaders Program of Nankai University ; State Key Laboratory of Drug Research[SIMM2004KF-13] ; Key Laboratory of Xinjiang Uygur Autonomous Region[2015KL030] ; Key Laboratory of Xinjiang Uygur Autonomous Region[2017D04019] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000552631700005 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292193]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Jing; Guo, Yuanqiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Nankai Univ, Coll Pharm, Tianjin Key Lab Mol Drug Res, State Key Lab Med Chem Biol, Tianjin 300050, Peoples R China 3.Nankai Univ, Drug Discovery Ctr Infect Dis, Tianjin 300050, Peoples R China 4.Nankai Univ, Sch Med, Tianjin 300071, Peoples R China 5.Kashgar Univ, Coll Chem & Environm Sci, Lab Xinjiang Nat Med & Edible Plant Resources Che, Kashgar 844000, Peoples R China 6.Korea Univ, Coll Life Sci & Biotechnol, Dept Biosyst & Biotechnol, Seoul 136713, South Korea |
| 推荐引用方式 GB/T 7714 | Wu, Peng,Song, Ziteng,Wang, Xuelian,et al. Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo[J]. BIOORGANIC CHEMISTRY,2020,101:10. |
| APA | Wu, Peng.,Song, Ziteng.,Wang, Xuelian.,Li, Ying.,Li, Yuhao.,...&Guo, Yuanqiang.(2020).Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo.BIOORGANIC CHEMISTRY,101,10. |
| MLA | Wu, Peng,et al."Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo".BIOORGANIC CHEMISTRY 101(2020):10. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。