Folded or Degraded in Endoplasmic Reticulum
文献类型：期刊论文
| 作者 | Li, Chushu1; Xia, Bingqing4; Wang, Sheng2; Xu, Jie3 |
| 刊名 | REGULATION OF CANCER IMMUNE CHECKPOINTS: MOLECULAR AND CELLULAR MECHANISMS AND THERAPY
 |
| 出版日期 | 2020 |
| 卷号 | 1248页码:265-294 |
| 关键词 | Immune checkpoint proteins Endoplasmic reticulum Glycosylation ER chaperones ER enzymes Protein folding COPII Vesicle trafficking ER proteostasis ER quality control ER stress UPR ERAD ERLAD Immunotherapy |
| ISSN号 | 0065-2598 |
| DOI | 10.1007/978-981-15-3266-5_12 |
| 通讯作者 | Xu, Jie(jie_xu@fudan.edu.cn) |
| 英文摘要 | In consistent with other membrane-bound and secretory proteins, immune checkpoint proteins go through a set of modifications in the endoplasmic reticulum (ER) to acquire their native functional structures before they function at their destinations. There are various ER-resident chaperones and enzymes synergistically regulate and catalyze the glycosylation, folding and transporting of proteins. The whole processing is under the surveillance of ER quality control system which allows the correctly folded proteins to exit from the ER with the help of coat proteinII(COPII) coated vesicles, while retains the rest of terminally misfolded ones in the ER and then eliminates them via ER-associated degradation (ERAD) or ER-to-lysosomes-associated degradation (ERLAD). The dysfunction of the ER causes ER stress which triggers unfolded protein response (UPR) to restore ER proteostasis. Unsolvable prolonged ER stress ultimately results in cell death. This chapter reviews the process that proteins undergo in the ER, and the glycosylation, folding and degradation of immune checkpoint proteins as well as the associated potential immunotherapies to date. |
| WOS关键词 | PROTEIN-DISULFIDE-ISOMERASE ; ER MANNOSIDASE-I ; QUALITY-CONTROL ; MEMBRANE-PROTEINS ; SACCHAROMYCES-CEREVISIAE ; BINDING-SPECIFICITY ; GOLGI LOCALIZATION ; ANTITUMOR IMMUNITY ; STRUCTURAL BASIS ; N-GLYCOSYLATION |
| WOS研究方向 | Oncology ; Immunology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000554918800012 |
| 出版者 | SPRINGER INTERNATIONAL PUBLISHING AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292218]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xu, Jie |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai, Peoples R China 2.Fudan Univ, Inst Biomed Sci, 130 Dongan Rd, Shanghai 200032, Peoples R China 3.Fudan Univ, Zhongshan Xuhui Hosp, Inst Biomed Sci, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Chushu,Xia, Bingqing,Wang, Sheng,et al. Folded or Degraded in Endoplasmic Reticulum[J]. REGULATION OF CANCER IMMUNE CHECKPOINTS: MOLECULAR AND CELLULAR MECHANISMS AND THERAPY,2020,1248:265-294. |
| APA | Li, Chushu,Xia, Bingqing,Wang, Sheng,&Xu, Jie.(2020).Folded or Degraded in Endoplasmic Reticulum.REGULATION OF CANCER IMMUNE CHECKPOINTS: MOLECULAR AND CELLULAR MECHANISMS AND THERAPY,1248,265-294. |
| MLA | Li, Chushu,et al."Folded or Degraded in Endoplasmic Reticulum".REGULATION OF CANCER IMMUNE CHECKPOINTS: MOLECULAR AND CELLULAR MECHANISMS AND THERAPY 1248(2020):265-294. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。