Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta
文献类型:期刊论文
作者 | Liu, Jiao1,4; Wu, Xin5; Yang, Min1,4; Gu, Yu-Cheng3; Yao, Li-Gong4; Huan, Xia-Juan4; Miao, Ze-Hong1,4; Luo, Hui5; Guo, Yue-Wei1,2,4 |
刊名 | STEROIDS |
出版日期 | 2020-09-01 |
卷号 | 161页码:5 |
ISSN号 | 0039-128X |
关键词 | Sinularia erecta Steroidal derivative Cytotoxicity Baeyer-Villiger oxidation |
DOI | 10.1016/j.steroids.2020.108681 |
通讯作者 | Luo, Hui(luohui@gdmu.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
英文摘要 | Two novel steroidal derivatives, erectsterates A (1) and B (2), a pair of epimers at C-10, were isolated from the South China Sea soft coral Sinularia erecta. Their structures were established by extensive spectroscopic analysis and deduction from biosynthesis route. Compounds 1 and 2 are rare steroids with a highly degradation in ring B and an ester linkage between A and C/D rings, similar with the known compounds chaxines B (3) and D from an edible mushroom Agrocybe chaxingu. To the best of our knowledge, this is the first report of such kind of steroid from soft coral. And a different biosynthetic route from the reported approach of chaxines was proposed in this paper. Interestingly, the ring C of 1 and 2 was formally oxidized by Baeyer-Villiger reaction to provide an unprecedented seven-membered lactone moiety in ring C of steroid. The in vitro anti-proliferative activities of 2 were evaluated against A549, HT-29, SNU-398 and Capan-1 cell lines. The results indicated that it showed weak cytotoxicity against the tested four cell lines. |
WOS关键词 | CASBANE DITERPENOIDS ; CONSTITUENTS |
资助项目 | National Key Research and Development Program of China[2018YFC0310903] ; Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Syngenta-SIMM-PhD Studentship Project |
WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE INC |
WOS记录号 | WOS:000554926100009 |
源URL | [http://119.78.100.183/handle/2S10ELR8/292221] |
专题 | 新药研究国家重点实验室 |
通讯作者 | Luo, Hui; Guo, Yue-Wei |
作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Jealotts Hill Int Res Ctr, Syngenta, Bracknell RG42 6EY, Berks, England 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 5.Guangdong Med Univ, Marine Biomed Res Inst, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Jiao,Wu, Xin,Yang, Min,et al. Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta[J]. STEROIDS,2020,161:5. |
APA | Liu, Jiao.,Wu, Xin.,Yang, Min.,Gu, Yu-Cheng.,Yao, Li-Gong.,...&Guo, Yue-Wei.(2020).Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta.STEROIDS,161,5. |
MLA | Liu, Jiao,et al."Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta".STEROIDS 161(2020):5. |
入库方式: OAI收割
来源:上海药物研究所
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