中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta

文献类型:期刊论文

作者Liu, Jiao1,4; Wu, Xin5; Yang, Min1,4; Gu, Yu-Cheng3; Yao, Li-Gong4; Huan, Xia-Juan4; Miao, Ze-Hong1,4; Luo, Hui5; Guo, Yue-Wei1,2,4
刊名STEROIDS
出版日期2020-09-01
卷号161页码:5
ISSN号0039-128X
关键词Sinularia erecta Steroidal derivative Cytotoxicity Baeyer-Villiger oxidation
DOI10.1016/j.steroids.2020.108681
通讯作者Luo, Hui(luohui@gdmu.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Two novel steroidal derivatives, erectsterates A (1) and B (2), a pair of epimers at C-10, were isolated from the South China Sea soft coral Sinularia erecta. Their structures were established by extensive spectroscopic analysis and deduction from biosynthesis route. Compounds 1 and 2 are rare steroids with a highly degradation in ring B and an ester linkage between A and C/D rings, similar with the known compounds chaxines B (3) and D from an edible mushroom Agrocybe chaxingu. To the best of our knowledge, this is the first report of such kind of steroid from soft coral. And a different biosynthetic route from the reported approach of chaxines was proposed in this paper. Interestingly, the ring C of 1 and 2 was formally oxidized by Baeyer-Villiger reaction to provide an unprecedented seven-membered lactone moiety in ring C of steroid. The in vitro anti-proliferative activities of 2 were evaluated against A549, HT-29, SNU-398 and Capan-1 cell lines. The results indicated that it showed weak cytotoxicity against the tested four cell lines.
WOS关键词CASBANE DITERPENOIDS ; CONSTITUENTS
资助项目National Key Research and Development Program of China[2018YFC0310903] ; Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Syngenta-SIMM-PhD Studentship Project
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种英语
出版者ELSEVIER SCIENCE INC
WOS记录号WOS:000554926100009
源URL[http://119.78.100.183/handle/2S10ELR8/292221]  
专题新药研究国家重点实验室
通讯作者Luo, Hui; Guo, Yue-Wei
作者单位1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
3.Jealotts Hill Int Res Ctr, Syngenta, Bracknell RG42 6EY, Berks, England
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
5.Guangdong Med Univ, Marine Biomed Res Inst, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China
推荐引用方式
GB/T 7714
Liu, Jiao,Wu, Xin,Yang, Min,et al. Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta[J]. STEROIDS,2020,161:5.
APA Liu, Jiao.,Wu, Xin.,Yang, Min.,Gu, Yu-Cheng.,Yao, Li-Gong.,...&Guo, Yue-Wei.(2020).Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta.STEROIDS,161,5.
MLA Liu, Jiao,et al."Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta".STEROIDS 161(2020):5.

入库方式: OAI收割

来源:上海药物研究所

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