Lysine demethylase KDM3A regulates nanophotonic hyperthermia resistance generated by 2D silicene in breast cancer
文献类型：期刊论文
| 作者 | He, Chao1; Yu, Luodan3; Ding, Li3; Yao, Heliang2; Chen, Yu3; Hao, Yongqiang1 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 255页码:12 |
| ISSN号 | 0142-9612 |
| 关键词 | Silicene Epigenetics KDM3A p53 Photothermal therapy |
| DOI | 10.1016/j.biomaterials.2020.120181 |
| 通讯作者 | Yu, Luodan(yuluodan@mail.sic.ac.cn) ; Chen, Yu(chenyu@mail.sic.ac.cn) ; Hao, Yongqiang(haoyq1664@sh9hospital.org.cn) |
| 英文摘要 | Breast cancer (BC) is the most common malignant disease affecting women's health worldwide. The benefits from conventional therapeutic modalities are severely limited. An increasing number of promising photothermal materials have been recently developed and introduced into the therapeutic regimens of BC, but the underlying biological mechanism remains unclear. Silicon-based materials have enjoyed many popularities in the biomedical field owing to their desirable biocompatibility, biodegradability and versatility. Herein, we introduced two dimensional (2D) silicene nanosheets (SNSs) into the BC treatment and achieved profound photothermal-ablation efficacy. Importantly, this work reveals the underlying biological mechanism and regulation factors of photonic hyperthermia in BC. The RNA sequencing and immunoblot demonstrated that photothermia enhanced apoptosis in BC by activating caspase 3 and caspase 7. Importantly, knockdown of lysine demethylase KDM3A sensitized BC to photothermia epigenetically. It has been revealed that KDM3A could erase p53K372me1 and suppress the anti-cancer functions of p53, leading to the downregulation of pro-apoptotic proteins-PUMA and NOXA verified by Co-IP and ChIP-qPCR assays. Therefore, our results not only import near infrared light (NIR) induced photothermal ablation generated by SNSs-BSA into the BC treatment, but also clarify the underlying mechanism and regulation factors for further photothermal performance optimization and clinical translation. |
| WOS关键词 | GENE-EXPRESSION ; P53 ACTIVITY ; HISTONE ; CHEMOTHERAPY ; METHYLATION ; MECHANISMS ; IMPACT ; JHDM2A ; PUMA |
| 资助项目 | National Key R&D Program of China[2016YFC1100600] ; National Key R&D Program of China[2016YFA0203700] ; National Natural Science Foundation of China[51672303] ; National Natural Science Foundation of China[81972058] ; Excellent Young Scientist Foundation of NSFC[51722211] ; Program of Shanghai Subject Chief Scientist[18XD1404300] ; Youth Program of National Natural Science Foundation of China[51902334] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000555693800026 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292269]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yu, Luodan; Chen, Yu; Hao, Yongqiang |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Key Lab Orthoped Implants, Dept Orthoped Surg, Shanghai Peoples Hosp 9,Sch Med, Shanghai 200011, Peoples R China 2.Chinese Acad Sci, Anal & Testing Ctr Inorgan Mat, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 3.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Chao,Yu, Luodan,Ding, Li,et al. Lysine demethylase KDM3A regulates nanophotonic hyperthermia resistance generated by 2D silicene in breast cancer[J]. BIOMATERIALS,2020,255:12. |
| APA | He, Chao,Yu, Luodan,Ding, Li,Yao, Heliang,Chen, Yu,&Hao, Yongqiang.(2020).Lysine demethylase KDM3A regulates nanophotonic hyperthermia resistance generated by 2D silicene in breast cancer.BIOMATERIALS,255,12. |
| MLA | He, Chao,et al."Lysine demethylase KDM3A regulates nanophotonic hyperthermia resistance generated by 2D silicene in breast cancer".BIOMATERIALS 255(2020):12. |
入库方式： OAI收割
来源：上海药物研究所
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