Dependence of PINK1 accumulation on mitochondrial redox system
文献类型：期刊论文
| 作者 | Gao, Feng1,3,4; Zhang, Yan1,3; Hou, Xiaoou1,3; Tao, Zhouteng1,2,3; Ren, Haigang1,3; Wang, Guanghui1,3 |
| 刊名 | AGING CELL
 |
| 出版日期 | 2020-08-11 |
| 页码 | 14 |
| 关键词 | autophagy mitochondrion mitophagy neurodegenerative diseases PINK1 |
| ISSN号 | 1474-9718 |
| DOI | 10.1111/acel.13211 |
| 通讯作者 | Gao, Feng(fenggao7@ustc.edu.cn) ; Wang, Guanghui(wanggh@suda.edu.cn) |
| 英文摘要 | Accumulation of PINK1 on the outer mitochondrial membrane (OMM) is necessary for PINK-mediated mitophagy. The proton ionophores, like carbonyl cyanide m-chlorophenylhydrazone (CCCP) and carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP), inhibit PINK1 import into mitochondrial matrix and induce PINK1 OMM accumulation. Here, we show that the CHCHD4/GFER disulfide relay system in the mitochondrial intermembrane space (IMS) is required for PINK1 stabilization when mitochondrial membrane potential is lost. Activation of CHCHD4/GFER system by mitochondrial oxidative stress or inhibition of CHCHD4/GFER system with antioxidants can promote or suppress PINK1 accumulation, respectively. Thus data suggest a pivotal role of CHCHD4/GFER system in PINK1 accumulation. The amyotrophic lateral sclerosis-related superoxide dismutase 1 mutants dysregulated redox state and CHCHD4/GFER system in the IMS, leading to inhibitions of PINK1 accumulation and mitophagy. Thus, the redox system in the IMS is involved in PINK1 accumulation and damaged mitochondrial clearance, which may play roles in mitochondrial dysfunction-related neurodegenerative diseases. |
| WOS关键词 | INTERMEMBRANE SPACE ; SUPEROXIDE-DISMUTASE ; PROTEIN IMPORT ; MITOPHAGY ; PARKIN ; SOD1 ; PHOSPHORYLATION ; RECRUITMENT ; UBIQUITIN ; DYSFUNCTION |
| 资助项目 | National Natural Sciences Foundation of China[81701255] ; National Natural Sciences Foundation of China[31871023] ; National Natural Sciences Foundation of China[31970966] ; National Key Plan for Scientific Research and Development of China[2016YFC1306000] ; National Key Plan for Scientific Research and Development of China[2016YFC1300500] ; Suzhou Clinical Research Center of Neurological Disease[Szzx201503] ; Priority Academic Program Development of Jiangsu Higher Education Institutions |
| WOS研究方向 | Cell Biology ; Geriatrics & Gerontology |
| 语种 | 英语 |
| WOS记录号 | WOS:000557897600001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292278]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Gao, Feng; Wang, Guanghui |
| 作者单位 | 1.Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacol, Suzhou 215123, Jiangsu, Peoples R China 2.Chinese Acad Sci, Ctr Drug Safety Evaluat & Res, State Key Lab New Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Disorders, Lab Mol Neuropathol, Suzhou 215123, Jiangsu, Peoples R China 4.Univ Sci & Technol China, Neurodegenerat Disorder Res Ctr, Div Life Sci & Med, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Feng,Zhang, Yan,Hou, Xiaoou,et al. Dependence of PINK1 accumulation on mitochondrial redox system[J]. AGING CELL,2020:14. |
| APA | Gao, Feng,Zhang, Yan,Hou, Xiaoou,Tao, Zhouteng,Ren, Haigang,&Wang, Guanghui.(2020).Dependence of PINK1 accumulation on mitochondrial redox system.AGING CELL,14. |
| MLA | Gao, Feng,et al."Dependence of PINK1 accumulation on mitochondrial redox system".AGING CELL (2020):14. |
入库方式： OAI收割
来源：上海药物研究所
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