Hyaluronic-acid-based beta-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol
文献类型：期刊论文
| 作者 | Singh, Parbeen2,3; Wu, Li3; Ren, Xiaohong3; Zhang, Wei3; Tang, Yan3; Chen, Yongli2; Carrier, Andrew1,4; Zhang, Xu1,2,4; Zhang, Jiwen3,5
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
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| 出版日期 | 2020-08-30 |
| 卷号 | 586页码:7 |
| 关键词 | Solubility enhancement Hyaluronic acid-beta-cyclodextrin grafted copolymer alpha-Tocopherol Inclusion complex |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2020.119542 |
| 通讯作者 | Zhang, Xu(Xu_Zhang@cbu.ca) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | Hyaluronic acid (HA), a common biopolymer found in the extracellular fluid, was grafted with beta-cyclodextrin (beta-CD) to form a composite polymer that could form inclusion complexes with tocopherol (VE), enhancing its water-solubility and serving as a model drug delivery system. Herein, different copolymers were prepared with varying HA:beta-CD ratios and characterized. VE loading capacity was directly correlated with increased beta-CD composition in the polymers and morphological changes were observed upon VE binding. The host materials and their VE inclusion complexes are not cytotoxic, and are thus useful for VE and drug delivery. |
| WOS关键词 | VITAMIN-E ; INCLUSION COMPLEX ; IN-VITRO ; PHOTOSTABILITY ; POLYMERS ; MATS |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] ; National Key R&D Program of China[2020YFE0201700] ; Post-doctoral Foundation Project of Shenzhen Polytechnic[6019330001K] ; Post-doctoral Foundation Project of Shenzhen Polytechnic[6019330006K] ; Post-doctoral Foundation Project of Shenzhen Polytechnic[6019330007K] ; China Postdoctoral Science Foundation[2019M653139] ; China Postdoctoral Science Foundation[2019M653979] ; Shenzhen Science and Technology Program[GJHZ20180928161212140] ; Guangdong Province Higher Vocational College & School's Pearl River Scholar Funded Scheme (2017) ; Canada Research Chairs program |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000557910700010 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292332]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Xu; Zhang, Jiwen |
| 作者单位 | 1.Cape Breton Univ, Dept Hlth Sci, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada 2.Shenzhen Polytech, Postdoctoral Innovat Practice Base, Shenzhen 518055, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Cape Breton Univ, Dept Chem, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada 5.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, 2 Tiantan Xili, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Singh, Parbeen,Wu, Li,Ren, Xiaohong,et al. Hyaluronic-acid-based beta-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2020,586:7. |
| APA | Singh, Parbeen.,Wu, Li.,Ren, Xiaohong.,Zhang, Wei.,Tang, Yan.,...&Zhang, Jiwen.(2020).Hyaluronic-acid-based beta-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol.INTERNATIONAL JOURNAL OF PHARMACEUTICS,586,7. |
| MLA | Singh, Parbeen,et al."Hyaluronic-acid-based beta-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol".INTERNATIONAL JOURNAL OF PHARMACEUTICS 586(2020):7. |
入库方式： OAI收割
来源：上海药物研究所
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