Enantioselective [4+2] Cycloaddition Reaction of Vinylquinolines with Dienals Enabled by Synergistic Organocatalysis
文献类型：期刊论文
| 作者 | Chen, Jing3,4; Fu, Yiwei3,4; Yu, Yang3,4; Wang, Jian-Rong2 ; Guo, Yue-Wei2; Li, Hao3,4; Wang, Wei1,3,4,5
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2020-08-07 |
| 卷号 | 22期号:15页码:6061-6066 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.0c02137 |
| 通讯作者 | Guo, Yue-Wei(ywguo@simm.ac.cn) ; Li, Hao(hli77@ecust.edu.cn) ; Wang, Wei(wwang@pharmacy.arizona.edu) |
| 英文摘要 | An unprecedented organocatalytic enantioselective [4 + 2] cycloaddition reaction of vinyl quinolines with dienals is achieved with the synergistic activation of CH3SO3H and a chiral aminocatalyst. The power of the process is demonstrated by its high efficiency of the production of new synthetically and biologically valued chiral quinoline architectures in high yields and with excellent enantioselectivities. |
| WOS关键词 | DIELS-ALDER REACTIONS ; CONJUGATE ADDITION ; BRONSTED ACID ; CATALYSIS ; PYRIDYLETHYLATION ; VINYLPYRIDINES ; TRIENAMINES ; CYCLIZATION ; EFFICIENT ; QUININE |
| 资助项目 | National Natural Science Foundation of China[21738002] ; National Natural Science Foundation of China[21572054] ; National Natural Science Foundation of China[21572055] ; program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning ; Fundamental Research Funds for the Central Universities ; China 111 Project[B07023] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000562077400068 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292380]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei; Li, Hao; Wang, Wei |
| 作者单位 | 1.Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China 4.East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China 5.Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA |
| 推荐引用方式 GB/T 7714 | Chen, Jing,Fu, Yiwei,Yu, Yang,et al. Enantioselective [4+2] Cycloaddition Reaction of Vinylquinolines with Dienals Enabled by Synergistic Organocatalysis[J]. ORGANIC LETTERS,2020,22(15):6061-6066. |
| APA | Chen, Jing.,Fu, Yiwei.,Yu, Yang.,Wang, Jian-Rong.,Guo, Yue-Wei.,...&Wang, Wei.(2020).Enantioselective [4+2] Cycloaddition Reaction of Vinylquinolines with Dienals Enabled by Synergistic Organocatalysis.ORGANIC LETTERS,22(15),6061-6066. |
| MLA | Chen, Jing,et al."Enantioselective [4+2] Cycloaddition Reaction of Vinylquinolines with Dienals Enabled by Synergistic Organocatalysis".ORGANIC LETTERS 22.15(2020):6061-6066. |
入库方式： OAI收割
来源：上海药物研究所
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