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Machine-Driven Chemoenzymatic Synthesis of Glycopeptide

文献类型：期刊论文

作者Zhang, Jiabin2; Liu, Ding2; Saikam, Varma2; Gadi, Madhusudhan R.2; Gibbons, Christopher2; Fu, Xuan2; Song, Heliang2; Yu, Jin4; Kondengaden, Shukkoor M.3; Wang, Peng G.2,3
刊名ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期2020-08-31
页码6
关键词automation chemoenzymatic synthesis machine-driven peptide synthesizer silica resin
ISSN号1433-7851
DOI10.1002/anie.202001124
通讯作者Wang, Peng G.(pwang11@gsu.edu) ; Wen, Liuqing(lwen@simm.ac.cn)
英文摘要Historically, researchers have put considerable effort into developing automation systems to prepare natural biopolymers such as peptides and oligonucleotides. The availability of such mature systems has significantly advanced the development of natural science. Over the past twenty years, breakthroughs in automated synthesis of oligosaccharides have also been achieved. A machine-driven platform for glycopeptide synthesis by a reconstructed peptide synthesizer is described. The designed platform is based on the use of an amine-functionalized silica resin to facilitate the chemical synthesis of peptides in organic solvent as well as the enzymatic synthesis of glycan epitopes in the aqueous phase in a single reaction vessel. Both syntheses were performed by a peptide synthesizer in a semiautomated manner.
WOS关键词SOLID-PHASE PEPTIDE ; ENZYMATIC-SYNTHESIS ; ANTITUMOR VACCINES ; GLYCOSYLTRANSFERASE ; EXPRESSION ; INDUCTION
资助项目National Institutes of Health[U01GM116263] ; Shanghai Institute of Materia Medica[2019000021]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000564021000001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/292385]  
专题中国科学院上海药物研究所
通讯作者Wang, Peng G.; Wen, Liuqing
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA
3.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
4.Imperial Coll London, Du Cane Rd, London W12 0NN, England
推荐引用方式
GB/T 7714		 Zhang, Jiabin,Liu, Ding,Saikam, Varma,et al. Machine-Driven Chemoenzymatic Synthesis of Glycopeptide[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:6.
APA Zhang, Jiabin.,Liu, Ding.,Saikam, Varma.,Gadi, Madhusudhan R..,Gibbons, Christopher.,...&Wen, Liuqing.(2020).Machine-Driven Chemoenzymatic Synthesis of Glycopeptide.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6.
MLA Zhang, Jiabin,et al."Machine-Driven Chemoenzymatic Synthesis of Glycopeptide".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):6.

入库方式： OAI收割

来源：上海药物研究所

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