Dynamic structure model of polyelectrolyte complex based controlled-release matrix tablets visualized by synchrotron radiation micro-computed tomography
文献类型：期刊论文
| 作者 | Yin, Xianzhen3; Li, Liang2; Gu, Xiangqin2; Wang, Huimin2; Wu, Li3; Qin, Wei3; Xiao, Tiqiao1; York, Peter4; Zhang, Jiwen3 ; Mao, Shirui2
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| 刊名 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
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| 出版日期 | 2020-11-01 |
| 卷号 | 116页码:9 |
| 关键词 | Chitosan-carrageenan matrix Sustained release Synchrotron radiation X-ray micro-tomography Microstructure Hydration dynamic |
| ISSN号 | 0928-4931 |
| DOI | 10.1016/j.msec.2020.111137 |
| 通讯作者 | Zhang, Jiwen(jwzhang@simm.ac.cn) ; Mao, Shirui(maoshirui@syphu.edu.cn) |
| 英文摘要 | Hydrophilic matrix tablets are the most commonly used dosage forms to fabricate oral controlled-release systems. It is highly desirable to design delivery system with novel mechanism to achieve sustained drug release through a simplified preparation process. The chitosan-anionic polymers based matrix tablets is assumed to produce self-assembly in the gastrointestinal tract, then transferring into film-coated tablets from original matrix type. But its dynamic behavior during dissolution process and the on-going internal microstructural changes during drug release were still in the dark. In this study, by using synchrotron radiation X-ray micro-tomography (SR-mu CT) with phase contrast imaging, the micro-structure characteristics of chitosan-lambda-carrageenan (CS-lambda-CG) matrix based tablets during the dissolution were successfully elucidated for the first time. The qualitative and quantitative analyses of intensity distribution distinguished a hydrated CS-lambda-CG layer from a solid core. Visualization based on 3D models provided quantitative details on the micro-structural characteristics of hydration dynamics. After CS-lambda-CG matrix tablets were immersed in simulated gastric fluid (SGF) pH 1.2 medium for 0.5-2.0 h, the hydrated layer transformed into a gel layer and a solid swollen layer. The erosion front, swelling front, and solvent penetration front were also defined from the distinguishable micro-structures. More importantly, once the matrix tablet was transferred from SGF to the simulated intestinal fluid (SIF) pH 6.8 medium, a new layer with the enhanced strength and compactness in comparison to common gels was formed on the surface of tablets. The temporal and spatial variation of 3D models further provided direct evidence for this cross-linking behavior, the new layer was composed of CS-lambda-CG polyelectrolyte complexes (PEC) which subsequently dominated release mechanisms. In summary, the phase contrast SR-mu CT technique was utilized to investigate the hydration dynamics of CS-lambda-CG matrix tablets which was supposed to provide a novel drug release mechanism. Based on the structure feature obtained from the high contrast image, different hydration region was distinguished and the cross-linked film was identified and visualized directly for the first time. |
| WOS关键词 | MAGNETIC-RESONANCE MICROSCOPY ; DRUG-RELEASE ; MORPHOLOGICAL-CHANGES ; EXCIPIENTS ; KINETICS ; DELIVERY |
| 资助项目 | National Natural Science Foundation of China[81773645] ; National Natural Science Foundation of China[81803446] ; Youth Innovation Promotion Association CAS[2018323] ; National Science and Technology Major Project[2017ZX09101001-006] ; Key Program for International Science and Technology Cooperation Projects of China[2019YFE020185] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000563473200003 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292420]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jiwen; Mao, Shirui |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 4.Univ Bradford, Bradford BD7 1DP, W Yorkshire, England |
| 推荐引用方式 GB/T 7714 | Yin, Xianzhen,Li, Liang,Gu, Xiangqin,et al. Dynamic structure model of polyelectrolyte complex based controlled-release matrix tablets visualized by synchrotron radiation micro-computed tomography[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2020,116:9. |
| APA | Yin, Xianzhen.,Li, Liang.,Gu, Xiangqin.,Wang, Huimin.,Wu, Li.,...&Mao, Shirui.(2020).Dynamic structure model of polyelectrolyte complex based controlled-release matrix tablets visualized by synchrotron radiation micro-computed tomography.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,116,9. |
| MLA | Yin, Xianzhen,et al."Dynamic structure model of polyelectrolyte complex based controlled-release matrix tablets visualized by synchrotron radiation micro-computed tomography".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 116(2020):9. |
入库方式： OAI收割
来源：上海药物研究所
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