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On-DNA Cross-Dehydrogenative Coupling Reaction toward the Synthesis of Focused DNA-Encoded Tetrahydroisoquinoline Libraries

文献类型：期刊论文

作者Wen, Xin1,2; Duan, Zhiqiang1; Liu, Jiaxiang1; Lu, Weiwei1; Lu, Xiaojie1,2
刊名ORGANIC LETTERS
出版日期2020-08-07
卷号22期号:15页码:5721-5725
ISSN号1523-7060
DOI10.1021/acs.orglett.0c01565
通讯作者Lu, Xiaojie(xjlu@simm.ac.cn)
英文摘要To expand the chemical space of DNA-encoded library (DEL) technology, we have developed the DNA-compatible cross-dehydrogenative coupling reaction between tetrahydroisoquinolines (THIQs) and a series of nucleophiles such as nitromethane, terminal alkynes, and so on. Both photo- and metal-promoted conditions have been successfully established for this C-1 derivation of THIQs, as exemplified by the addition of nitromethane. All of these new DNA-compatible transformations have paved the way for the divergent oriented synthesis of THIQ-focused DELs.
WOS关键词SP(3) C-H ; ALKYLATION ; DISCOVERY ; DESIGN ; ALKYNYLATION ; TECHNOLOGY ; SELECTION
资助项目National Natural Science Foundation of China[21877117] ; National Natural Science Foundation of China[91953203] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-005] ; Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040330] ; Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050405] ; Shanghai Commission of Science and Technology[18431907100]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000562077400002
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/292469]  
专题新药研究国家重点实验室
通讯作者Lu, Xiaojie
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wen, Xin,Duan, Zhiqiang,Liu, Jiaxiang,et al. On-DNA Cross-Dehydrogenative Coupling Reaction toward the Synthesis of Focused DNA-Encoded Tetrahydroisoquinoline Libraries[J]. ORGANIC LETTERS,2020,22(15):5721-5725.
APA Wen, Xin,Duan, Zhiqiang,Liu, Jiaxiang,Lu, Weiwei,&Lu, Xiaojie.(2020).On-DNA Cross-Dehydrogenative Coupling Reaction toward the Synthesis of Focused DNA-Encoded Tetrahydroisoquinoline Libraries.ORGANIC LETTERS,22(15),5721-5725.
MLA Wen, Xin,et al."On-DNA Cross-Dehydrogenative Coupling Reaction toward the Synthesis of Focused DNA-Encoded Tetrahydroisoquinoline Libraries".ORGANIC LETTERS 22.15(2020):5721-5725.

入库方式： OAI收割

来源：上海药物研究所

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