Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications
文献类型：期刊论文
| 作者 | Weber, Maria2,3; Han, Hai-Hao4,5,6; Li, Bo-Han4,7; Odyniec, Maria L.2; Jarman, Charlotte E. F.2; Zang, Yi4 ; Bull, Steven D.2; Mackenzie, Amanda B.1,9; Sedgwick, Adam C.8; Li, Jia4,7
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| 刊名 | CHEMICAL SCIENCE
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| 出版日期 | 2020-08-21 |
| 卷号 | 11期号:32页码:8567-8571 |
| ISSN号 | 2041-6520 |
| DOI | 10.1039/d0sc02438d |
| 通讯作者 | Sedgwick, Adam C.(a.c.sedgwick@utexas.edu) ; Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; James, Tony D.(t.d.james@bath.ac.uk) |
| 英文摘要 | Reaction-based fluorescent-probes have proven successful for the visualisation of biological species in various cellular processes. Unfortunately, in order to tailor the design of a fluorescent probe to a specific application (i.e.organelle targeting, material and theranostic applications) often requires extensive synthetic efforts and the synthetic screening of a range of fluorophores to match the required synthetic needs. In this work, we have identifiedPinkment-OHas a unique "plug-and-play" synthetic platform that can be used to develop a range of ONOO(-)responsive fluorescent probes for a variety of applications. These include theranostic-based applications and potential material-based/bioconjugation applications. The as prepared probes displayed an excellent sensitivity and selectivity for ONOO(-)over other ROS.In vitrostudies using HeLa cells and RAW 264.7 macrophages demonstrated their ability to detect exogenously and endogenously produced ONOO-. Evaluation in an LPS-induced inflammation mouse model illustrated the ability to monitor ONOO(-)production in acute inflammation. Lastly, theranostic-based probes enabled the simultaneous evaluation of indomethacin-based therapeutic effects combined with the visualisation of an inflammation biomarker in RAW 264.7 cells. |
| WOS关键词 | CLICK-CHEMISTRY ; HYDROGEN-PEROXIDE ; REACTIVE OXYGEN ; NITRIC-OXIDE ; PEROXYNITRITE ; ANTIOXIDANTS ; HEALTH |
| 资助项目 | EPSRC[EP/L016354/1] ; University of Bath ; EPSRC ; Royal Society ; National Natural Science Foundation of China[21788102] ; National Natural Science Foundation of China[91853201] ; National Natural Science Foundation of China[21722801] ; National Natural Science Foundation of China[21776078] ; National Key Sci-Tech Special Projects of Infection Diseases of China[2018ZX10732202] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; International Cooperation Program of Shanghai Science and Technology Committee[17520750100] ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000561022500020 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292479]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Sedgwick, Adam C.; Li, Jia; He, Xiao-Peng; James, Tony D. |
| 作者单位 | 1.Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England 2.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 3.Univ Bath, Ctr Sustainable & Circular Technol, Ctr Doctoral Training, Bath BA2 7AY, Avon, England 4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China 5.East China Univ Sci & Technol, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China 6.East China Univ Sci & Technol, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, 130 Meilong Rd, Shanghai 200237, Peoples R China 7.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 8.Univ Texas Austin, Dept Chem, 105 East 24th St A5300, Austin, TX 78712 USA 9.Univ Bath, Ctr Therapeut Innovat, Bath BA2 7AY, Avon, England |
| 推荐引用方式 GB/T 7714 | Weber, Maria,Han, Hai-Hao,Li, Bo-Han,et al. Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications[J]. CHEMICAL SCIENCE,2020,11(32):8567-8571. |
| APA | Weber, Maria.,Han, Hai-Hao.,Li, Bo-Han.,Odyniec, Maria L..,Jarman, Charlotte E. F..,...&James, Tony D..(2020).Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications.CHEMICAL SCIENCE,11(32),8567-8571. |
| MLA | Weber, Maria,et al."Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications".CHEMICAL SCIENCE 11.32(2020):8567-8571. |
入库方式： OAI收割
来源：上海药物研究所
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