Polyprenylated acylphloroglucinols as deubiquitinating protease USP7 inhibitors from Hypericum hookerianum
文献类型：期刊论文
| 作者 | Wang, Qi-Qi1,2; Wang, Xiao-Dong3; Wu, Ling-Zhi4; Fang, Qiang-Qiang1,2; Liu, Ya-Nan1,2; Jiang, Kun2; Qu, Shi-Jin2 ; Tan, Chang-Heng1,2
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 146页码:5 |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2020.104678 |
| 通讯作者 | Qu, Shi-Jin(sjqu@simm.ac.cn) ; Tan, Chang-Heng(chtan@simm.ac.cn) |
| 英文摘要 | Hookerianones A - E (1-5), five new polyprenylated acylphloroglucinols (PPAPs), along with six known ones, were isolated from the aerial parts of Hypericum hookerianum. Their structures were elucidated by analyses of MS, NMR, chiroptical properties, biogenetic pathway, and/or single crystal X-ray diffraction. A ubiquitin-rhodamine 110 assay showed that furohyperforin and hypercalin C, two representative PPAPs in this plant, inhibited more than 90% USP7 at the concentration of 10 mu M. |
| WOS关键词 | PHLOROGLUCINOL DERIVATIVES ; A-H |
| 资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2019ZX09201001] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2018ZX09735001-002-005] ; Ministry of Science and Technology, China |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000580427700024 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292490]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Qu, Shi-Jin; Tan, Chang-Heng |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China 3.Sichuan Univ, West China Hosp, Inst Hosp Management, Chengdu 610041, Peoples R China 4.Beijing Inst Life, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing Proteome Res Ctr, Beijing 102206, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qi-Qi,Wang, Xiao-Dong,Wu, Ling-Zhi,et al. Polyprenylated acylphloroglucinols as deubiquitinating protease USP7 inhibitors from Hypericum hookerianum[J]. FITOTERAPIA,2020,146:5. |
| APA | Wang, Qi-Qi.,Wang, Xiao-Dong.,Wu, Ling-Zhi.,Fang, Qiang-Qiang.,Liu, Ya-Nan.,...&Tan, Chang-Heng.(2020).Polyprenylated acylphloroglucinols as deubiquitinating protease USP7 inhibitors from Hypericum hookerianum.FITOTERAPIA,146,5. |
| MLA | Wang, Qi-Qi,et al."Polyprenylated acylphloroglucinols as deubiquitinating protease USP7 inhibitors from Hypericum hookerianum".FITOTERAPIA 146(2020):5. |
入库方式： OAI收割
来源：上海药物研究所
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