Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China
文献类型：期刊论文
| 作者 | Zhu, Lin1,6; Zhang, Chun-yuan1,6; Li, Dong-ping2; Chen, Hu-biao3; Ma, Jiang1,6; Gao, Hong2; Ye, Yang1,5 ; Wang, Ji-yao2; Fu, Peter P.4; Lin, Ge1,6
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2020-11-05 |
| 页码 | 11 |
| ISSN号 | 1671-4083 |
| 关键词 | herb-induced liver injury hepatic sinusoidal obstruction syndrome pyrrolizidine alkaloids Tu-San-Qi Gynura japonica |
| DOI | 10.1038/s41401-020-00553-9 |
| 通讯作者 | Lin, Ge(linge@cuhk.edu.hk) |
| 英文摘要 | Herbs and dietary supplement-induced liver injury (HILI) is the leading cause of drug-induced liver injury in China. Among different hepatotoxic herbs, the pyrrolizidine alkaloid (PA)-producing herb Gynura japonica contributes significantly to HILI by inducing hepatic sinusoidal obstruction syndrome (HSOS), a liver disorder characterized by hepatomegaly, hyperbilirubinemia, and ascites. In China, G. japonica has been used as one of the plant species for Tu-San-Qi and is often misused with non-PA-producing Tu-San-Qi (Sedum aizoon) or even San-Qi (Panax notoginseng) for self-medication. It has been reported that over 50% of HSOS cases are caused by the intake of PA-producing G. japonica. In this review, we provide comprehensive information to distinguish these Tu-San-Qi-related herbal plant species in terms of plant/medicinal part morphologies, medicinal indications, and chemical profiles. Approximately 2156 Tu-San-Qi-associated HSOS cases reported in China from 1980 to 2019 are systematically reviewed in terms of their clinical manifestation, diagnostic workups, therapeutic interventions, and outcomes. In addition, based on the application of our developed mechanism-based biomarker of PA exposure, our clinical findings on the definitive diagnosis of 58 PA-producing Tu-San-Qi-induced HSOS patients are also elaborated. Therefore, this review article provides the first comprehensive report on 2214 PA-producing Tu-San-Qi (G. japonica)-induced HSOS cases in China, and the information presented will improve public awareness of the significant incidence of PA-producing Tu-San-Qi (G. japonica)-induced HSOS and facilitate future prevention and better clinical management of this severe HILI. |
| WOS关键词 | SINUSOIDAL OBSTRUCTION SYNDROME ; HEPATIC VENOOCCLUSIVE DISEASE ; PYRROLE-PROTEIN ADDUCTS ; DIAGNOSIS ; PLANTS ; DEFIBROTIDE ; METABOLISM ; COMPONENTS ; MEDICINES ; BIOMARKER |
| 资助项目 | Research Grant Council of Hong Kong (GRF)[14111816] ; Research Grant Council of Hong Kong (GRF)[14106318] ; CUHK Project Impact Enhancement Fund (PIEF)[3133029] ; CUHK Direct Grant[4054503] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000586355900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292503]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lin, Ge |
| 作者单位 | 1.Chinese Acad Sci, Chinese Univ Hong Kong & Shanghai Inst Mat Med, Joint Res Lab Promoting Globalizat Tradit Chinese, Beijing 201203, Peoples R China 2.Fudan Univ, Zhongshan Hosp, Div Gastroenterol, Shanghai 201203, Peoples R China 3.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Peoples R China 4.US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Nat Prod Chem Dept, Shanghai 201203, Peoples R China 6.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Lin,Zhang, Chun-yuan,Li, Dong-ping,et al. Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China[J]. ACTA PHARMACOLOGICA SINICA,2020:11. |
| APA | Zhu, Lin.,Zhang, Chun-yuan.,Li, Dong-ping.,Chen, Hu-biao.,Ma, Jiang.,...&Lin, Ge.(2020).Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China.ACTA PHARMACOLOGICA SINICA,11. |
| MLA | Zhu, Lin,et al."Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China".ACTA PHARMACOLOGICA SINICA (2020):11. |
入库方式： OAI收割
来源：上海药物研究所
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