Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging
文献类型:期刊论文
作者 | Li, Shilin2,3,4; Zhu, Nanlin1; Tang, Chunping4; Duan, Haonan1; Wang, Yongwei5; Zhao, Guangrong2,3; Liu, Jia1; Ye, Yang4 |
刊名 | FITOTERAPIA |
出版日期 | 2020-10-01 |
卷号 | 146页码:9 |
ISSN号 | 0367-326X |
关键词 | MALDI Mass spectrometry imaging Salvia miltiorrhiza Salvianolic acid Tanshinone |
DOI | 10.1016/j.fitote.2020.104679 |
通讯作者 | Zhao, Guangrong(grzhao@tju.edu.cn) ; Liu, Jia(jia.liu@simm.ac.cn) ; Ye, Yang(yye@simm.ac.cn) |
英文摘要 | Segmentation-quantification is the most commonly used method for studying the tissue distribution of bioactive constituents in plant, but this method would bring uncontrollable pollution, compound migration and denaturation. Mass spectrometry imaging (MSI), as a new method developed in the past 20 years, has high sensitivity, high spatial resolution, high degree of visualization, and low risk of contamination and degeneration when studying tissue distribution of compounds. For the first time we applied matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to tissue distribution of characteristic constituents of the medicinal plant Salvia miltiorrhiza. From the collected data, we found the regional differences in root, stem, and leaf tissues, and the ion information with differential distribution characteristics. We also identified 18 bioactive constituents in S. miltiorrhiza with their spatial distribution information. In addition, the plant was divided into five parts, and the identified compounds were analyzed for differences between tissues using LC-MS, which results verified those found from the MSI. It is figured out that MALDI-MSI can be reliably applied to the differential distribution of salvianolic acids and tanshinones. |
WOS关键词 | INHIBITION ; DANSHENSU |
资助项目 | National Natural Science Foundation of China[21920102003] |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000580427700025 |
源URL | [http://119.78.100.183/handle/2S10ELR8/292510] |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Zhao, Guangrong; Liu, Jia; Ye, Yang |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Tianjin Univ, Sch Chem Engn & Technol, Minist Educ, Frontier Sci Ctr Synthet Biol, Tianjin 300350, Peoples R China 3.Tianjin Univ, Sch Chem Engn & Technol, Minist Educ, Key Lab Syst Bioengn, Tianjin 300350, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 5.Bruker Beijing Sci Technol Co Ltd, Beijing 100192, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Shilin,Zhu, Nanlin,Tang, Chunping,et al. Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging[J]. FITOTERAPIA,2020,146:9. |
APA | Li, Shilin.,Zhu, Nanlin.,Tang, Chunping.,Duan, Haonan.,Wang, Yongwei.,...&Ye, Yang.(2020).Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging.FITOTERAPIA,146,9. |
MLA | Li, Shilin,et al."Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging".FITOTERAPIA 146(2020):9. |
入库方式: OAI收割
来源:上海药物研究所
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