Structurally diverse halosesquiterpenoids from the red alga Laurencia composita Yamada
文献类型：期刊论文
| 作者 | Hu, Zhi-Biao2; Yu, Xiao-Qing2; Wang, Bin2; Liu, Ai-Hong3; Zhao, Tian-Sheng2; Guo, Yue-Wei1 ; Huang, Hui-Lian4; Mao, Shui-Chun2
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 146页码:9 |
| ISSN号 | 0367-326X |
| 关键词 | Laurencia composita Chamigrane sesquiterpenoids Bisabolane sesquiterpenoids Nerolidol derivative Modified Mosher's method Antifungal activity Antibacterial activity |
| DOI | 10.1016/j.fitote.2020.104716 |
| 通讯作者 | Mao, Shui-Chun(maoshuichun@ncu.edu.cn) |
| 英文摘要 | A phytochemical investigation on the MeOH extract of the red alga Laurencia composita Yamada led to the discovery of six new highly halogenated sesquiterpenoids, including two bisabolane-type sesquiterpenoids (1 and 2), one nerolidol derivative (7), and three chamigrane-type sesquiterpenoids (9, 10, and 18), together with 13 known sesquiterpenoids. Their structures, including relative configuration, were elucidated by extensive spectroscopic analysis, and by comparison with data for related known compounds. The absolute configuration at C-10 of laurecomposin A (1) was determined by the modified Mosher's method. Halonerolidol (7) is the first naturally occurring halogenated nerolidol derivative, while compositacin L (9) represents the third example of chamigranes having a C-10 carbonyl group. Antifungal, antibacterial, and receptor tyrosine kinase inhibitory activities of these isolates were evaluated. The results showed that compounds 1-3 and 5 exhibited significant antifungal activity against Microsporum gypseum (Cmccfmza) with MIC values of 4, 8, 8, and 4 mu g/mL, respectively. Additionally, compounds 1-3 and 5 also displayed promising antibacterial activity against Gram-positive bacteria Staphylococcus aureus Newman strain with MIC values ranging from 10.9 to 26.8 mu g/mL. |
| WOS关键词 | ABSOLUTE-CONFIGURATIONS ; CHAMIGRENE DERIVATIVES ; LAURANE SESQUITERPENE ; CONSTITUENTS ; CHEMISTRY ; PRODUCTS |
| 资助项目 | National Natural Science Foundation of China[21362024] ; National Natural Science Foundation of China[81860616] ; Natural Science Foundation of Jiangxi Province, China[20151BAB205082] ; Natural Science Foundation of Jiangxi Province, China[20161BAB205211] ; Natural Science Foundation of Jiangxi Province, China[20181BAB205086] ; State Key Laboratory of Drug Research-SIMM[SIMM1803KF-01] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000580427700062 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292533]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Mao, Shui-Chun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China 3.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Jiangxi, Peoples R China 4.Jiangxi Univ Tradit Chinese Med, Coll Pharm, Nanchang 330004, Jiangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Zhi-Biao,Yu, Xiao-Qing,Wang, Bin,et al. Structurally diverse halosesquiterpenoids from the red alga Laurencia composita Yamada[J]. FITOTERAPIA,2020,146:9. |
| APA | Hu, Zhi-Biao.,Yu, Xiao-Qing.,Wang, Bin.,Liu, Ai-Hong.,Zhao, Tian-Sheng.,...&Mao, Shui-Chun.(2020).Structurally diverse halosesquiterpenoids from the red alga Laurencia composita Yamada.FITOTERAPIA,146,9. |
| MLA | Hu, Zhi-Biao,et al."Structurally diverse halosesquiterpenoids from the red alga Laurencia composita Yamada".FITOTERAPIA 146(2020):9. |
入库方式： OAI收割
来源：上海药物研究所
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