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Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis

文献类型：期刊论文

作者Qu, Yi1; Liu, Sixiu2,3; Wen, Huanan1; Xu, Yanfen1; An, Yulong1; Li, Ke1; Ni, Mengyuan1; Shen, Yanfang1; Shi, Xiaodong1; Su, Wenji1
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2020-12-03
卷号533期号:2页码:209-214
关键词DNA Encoded chemistry Suzuki-miyaura cross-coupling Potassium trifluoroborates
ISSN号0006-291X
DOI10.1016/j.bbrc.2020.04.027
通讯作者Lu, Xiaojie(xjlu@simm.ac.cn) ; Peng, Xuanjia(peng.xuanjia@wuxiapptec.com)
英文摘要A mild reaction for DNA-compatible, palladium promoted Suzuki-Miyaura cross-coupling reaction of potassium Boc-protected aminomethyltrifluoroborate with DNA-conjugated aryl bromides has been developed efficiently. This novel DNA encoded chemistry reaction proceeded well with a wide range of functional group tolerance, including aryl bromides and heteroaryl bromides. Further, the utility our DNA conjugated aminomethylated arene products is demonstrated by reaction with various types of reagents (including amide formation with carboxylic acids, alkylation with aldehydes, and carbamoylation with amines) as would be desired for the production of a DNA encoded library. (C) 2020 Elsevier Inc. All rights reserved.
WOS关键词DESIGN ; SELECTION ; SYSTEM
资助项目National Natural Science Foundation ofChina[21877117] ; National Natural Science Foundation ofChina[91953203] ; National Science& TechnologyMajor Project KeyNewDrug Creation and Manufacturing Program, China[2018ZX09711002-005] ; PersonalizedMedicinesdMolecular Signature-based Drug Discovery and Development, Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040330] ; PersonalizedMedicinesdMolecular Signature-based Drug Discovery and Development, Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050405] ; Shanghai Commission of Science and Technology[18431907100]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000583921700003
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/292549]  
专题新药研究国家重点实验室
通讯作者Lu, Xiaojie; Peng, Xuanjia
作者单位1.WuXi AppTec, DNA Encoded Lib Platform, 288 Fute Zhong Rd, Shanghai 200131, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Qu, Yi,Liu, Sixiu,Wen, Huanan,et al. Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020,533(2):209-214.
APA Qu, Yi.,Liu, Sixiu.,Wen, Huanan.,Xu, Yanfen.,An, Yulong.,...&Peng, Xuanjia.(2020).Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,533(2),209-214.
MLA Qu, Yi,et al."Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533.2(2020):209-214.

入库方式： OAI收割

来源：上海药物研究所

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