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Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases

文献类型：期刊论文

作者Zhao, Yuge2,3,4; Yang, Yuting2,3; Zhang, Jiaxin1,2; Wang, Rong2,3; Cheng, Biyun2,4; Kalambhe, Dipika2,4; Wang, Yingshu1,2; Gu, Zeyun2,4; Chen, Dongying2,5; Wang, Bing2
刊名ACTA PHARMACEUTICA SINICA B
出版日期2020-10-01
卷号10期号:10页码:1966-1976
关键词Targeting delivery Macrophages Patchouli alcohol Liposome Inflammatory bowel disease Colitis
ISSN号2211-3835
DOI10.1016/j.apsb.2020.07.019
通讯作者Chen, Dongying(dychen@simm.ac.cn) ; Wang, Bing(bwang@simm.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Inflammatory bowel diseases (IBD) are the incurable chronic recurrent gastrointestinal disorders and currently lack in safe and effective drugs. In this study, patchouli alcohol, a main active compound of traditional Chinese herb patchouli, was developed into biomimetic liposomes for macrophage-targeting delivery for IBD treatment. The developed lactoferrin-modified liposomes (LF-lipo) can specifically bind to LRP-1 expressed on the activated colonic macrophages and achieve cell-targeting anti-inflammatory therapy. LF-lipo reduced the levels of inflammatory cytokines and ROS and suppressed the MAPK/NF-kappa B pathway. LF-lipo also suppressed the formation of NLRP3 inflammasome and the consequent IL-1 beta activation. LF-lipo showed improved therapeutic efficacy in a DSS-induced colitis murine model, evidenced by the reduced disease activity index, the improved colon functions, and the downregulated inflammatory cytokines in the colon. LF-lipo provided an effective and safe macrophage-targeting delivery and therapeutic strategy for addressing the unmet medical need in IBD management. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
WOS关键词FACTOR-KAPPA-B ; INTESTINAL INFLAMMATION ; EXPERIMENTAL COLITIS ; CELL ; HOMEOSTASIS ; ACTIVATION ; MODELS ; OIL
资助项目National Natural Science Foundation of China[81925035] ; National Natural Science Foundation of China[81673382] ; National Natural Science Foundation of China[81521005] ; Strategic Priority Research Program of Chinese Academy of Sciences (China)[XDA12050307] ; National Special Project for Significant New Drugs Development (China)[2018ZX09711002-010-002] ; Shanghai SciTech Innovation Initiative (China)[19431903100] ; Shanghai SciTech Innovation Initiative (China)[18430740800] ; Fudan-SIMM Joint Research Fund (China)[FU-SIMM20174009]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000585230600013
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/292593]  
专题新药研究国家重点实验室
通讯作者Chen, Dongying; Wang, Bing; Huang, Yongzhuo
作者单位1.Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Pharmaceut Anal, Shanghai 201203, Peoples R China
6.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Shanghai 201203, Peoples R China
7.Chinese Acad Sci, Inst Drug Res & Dev, Zhongshan Branch, Zhongshan 528437, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Yuge,Yang, Yuting,Zhang, Jiaxin,et al. Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases[J]. ACTA PHARMACEUTICA SINICA B,2020,10(10):1966-1976.
APA Zhao, Yuge.,Yang, Yuting.,Zhang, Jiaxin.,Wang, Rong.,Cheng, Biyun.,...&Huang, Yongzhuo.(2020).Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases.ACTA PHARMACEUTICA SINICA B,10(10),1966-1976.
MLA Zhao, Yuge,et al."Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases".ACTA PHARMACEUTICA SINICA B 10.10(2020):1966-1976.

入库方式： OAI收割

来源：上海药物研究所

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