Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides
文献类型：期刊论文
| 作者 | Shi, Qing1; Li, Teng-Teng2,3,4; Wu, Yong-Mei3; Sun, Xin-Yu3; Lei, Chun1; Li, Jing-Ya3,4 ; Hou, Ai-Jun1
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2020-12-01 |
| 卷号 | 180页码:11 |
| 关键词 | Rhododendron anthopogonoides Maxim Ericaceae Meroterpenoids Anthoponoids A-I Daurichromene D Anti-inflammation |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2020.112524 |
| 通讯作者 | Li, Jing-Ya(jyli@simm.ac.cn) ; Hou, Ai-Jun(ajhou@shmu.edu.cn) |
| 英文摘要 | Eight pairs of meroterpenoid enantiomers and four achiral meroterpenoids were isolated from Rhododendron anthopogonoides Maxim. Seventeen of them, named (+)-/(-)-anthoponoids A-G, (+)-daurichromene D, and anthoponoids H and I, are undescribed compounds with structural diversity. Their structures were characterized herein by a combined application of spectroscopic techniques, X-ray crystallographic analysis, ECD calculation, and the modified Mosher's method. (+)-/(-)-Anthoponoid A and anthoponoid I are the first Rhododendron meroterpenoids found to possess a hexahydroxanthene motif and a diterpene unit, respectively. Some isolates were identified as NF-kappa B pathway inhibitors, and (+)-anthoponoid E, (-)-anthoponoid G, and anthoponoid H showed suppressive effects on LPS-induced inflammatory responses in RAW 264.7 macrophages. |
| WOS关键词 | GRAYANANE DITERPENOIDS ; ENANTIOMERIC PAIRS ; INFLAMMATION ; CANNABIDIOL ; DERIVATIVES ; (+/-)-RHODONOIDS ; IDENTIFICATION ; ERICACEAE ; MECHANISM ; CHROMANE |
| 资助项目 | Fudan-SIMM Joint Research Fund[FU-SIMM20181011] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000591773300013 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292605]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Jing-Ya; Hou, Ai-Jun |
| 作者单位 | 1.Fudan Univ, Sch Pharm, State Key Lab Med Neurobiol, Shanghai 201203, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Qing,Li, Teng-Teng,Wu, Yong-Mei,et al. Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides[J]. PHYTOCHEMISTRY,2020,180:11. |
| APA | Shi, Qing.,Li, Teng-Teng.,Wu, Yong-Mei.,Sun, Xin-Yu.,Lei, Chun.,...&Hou, Ai-Jun.(2020).Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides.PHYTOCHEMISTRY,180,11. |
| MLA | Shi, Qing,et al."Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides".PHYTOCHEMISTRY 180(2020):11. |
入库方式： OAI收割
来源：上海药物研究所
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