中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Teratopyrones A-C, Dimeric Naphtho-gamma-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense

文献类型:期刊论文

作者Xu, Ya-Ming3; Arnold, A. Elizabeth2; U'Ren, Jana M.2; Xuan, Li-Jiang1; Wang, Wen-Qiong1; Gunatilaka, A. A. Leslie3
刊名MOLECULES
出版日期2020-11-01
卷号25期号:21页码:10
关键词endophytic fungus Teratosphaeria teratopyrones naphtho-γ -pyrones nigerasperone A
DOI10.3390/molecules25215058
通讯作者Gunatilaka, A. A. Leslie(leslieg@cals.arizona.edu)
英文摘要Bioassay-guided fractionation of a cytotoxic extract derived from a solid potato dextrose agar (PDA) culture of Teratosphaeria sp. AK1128, a fungal endophyte of Equisetum arvense, afforded three new naphtho-gamma-pyrone dimers, teratopyrones A-C (1-3), together with five known naphtho-gamma-pyrones, aurasperone B (4), aurasperone C (5), aurasperone F (6), nigerasperone A (7), and fonsecin B (8), and two known diketopiperazines, asperazine (9) and isorugulosuvine (10). The structures of 1-3 were determined on the basis of their spectroscopic data. Cytotoxicity assay revealed that nigerasperone A (7) was moderately active against the cancer cell lines PC-3M (human metastatic prostate cancer), NCI-H460 (human non-small cell lung cancer), SF-268 (human CNS glioma), and MCF-7 (human breast cancer), with IC(50)s ranging from 2.37 to 4.12 mu M while other metabolites exhibited no cytotoxic activity up to a concentration of 5.0 mu M.
WOS关键词ASPERGILLUS ; MYCOSPHAERELLA ; DIVERSITY ; PLANT
资助项目National Institutes of Health[R01 CA090625] ; National Institutes of Health[P41 GM094060]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:000589391000001
源URL[http://119.78.100.183/handle/2S10ELR8/292653]  
专题新药研究国家重点实验室
通讯作者Gunatilaka, A. A. Leslie
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
2.Univ Arizona, Coll Agr & Life Sci, Sch Plant Sci, Tucson, AZ 85721 USA
3.Univ Arizona, Coll Agr & Life Sci, Southwest Ctr Nat Prod Res, Sch Nat Resources & Environm, 250 E,Valencia Rd, Tucson, AZ 85706 USA
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Xu, Ya-Ming,Arnold, A. Elizabeth,U'Ren, Jana M.,et al. Teratopyrones A-C, Dimeric Naphtho-gamma-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense[J]. MOLECULES,2020,25(21):10.
APA Xu, Ya-Ming,Arnold, A. Elizabeth,U'Ren, Jana M.,Xuan, Li-Jiang,Wang, Wen-Qiong,&Gunatilaka, A. A. Leslie.(2020).Teratopyrones A-C, Dimeric Naphtho-gamma-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense.MOLECULES,25(21),10.
MLA Xu, Ya-Ming,et al."Teratopyrones A-C, Dimeric Naphtho-gamma-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense".MOLECULES 25.21(2020):10.

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来源:上海药物研究所

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