Teratopyrones A-C, Dimeric Naphtho-gamma-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense
文献类型：期刊论文
| 作者 | Xu, Ya-Ming3; Arnold, A. Elizabeth2; U'Ren, Jana M.2; Xuan, Li-Jiang1 ; Wang, Wen-Qiong1; Gunatilaka, A. A. Leslie3
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| 刊名 | MOLECULES
 |
| 出版日期 | 2020-11-01 |
| 卷号 | 25期号:21页码:10 |
| 关键词 | endophytic fungus Teratosphaeria teratopyrones naphtho-γ -pyrones nigerasperone A |
| DOI | 10.3390/molecules25215058 |
| 通讯作者 | Gunatilaka, A. A. Leslie(leslieg@cals.arizona.edu) |
| 英文摘要 | Bioassay-guided fractionation of a cytotoxic extract derived from a solid potato dextrose agar (PDA) culture of Teratosphaeria sp. AK1128, a fungal endophyte of Equisetum arvense, afforded three new naphtho-gamma-pyrone dimers, teratopyrones A-C (1-3), together with five known naphtho-gamma-pyrones, aurasperone B (4), aurasperone C (5), aurasperone F (6), nigerasperone A (7), and fonsecin B (8), and two known diketopiperazines, asperazine (9) and isorugulosuvine (10). The structures of 1-3 were determined on the basis of their spectroscopic data. Cytotoxicity assay revealed that nigerasperone A (7) was moderately active against the cancer cell lines PC-3M (human metastatic prostate cancer), NCI-H460 (human non-small cell lung cancer), SF-268 (human CNS glioma), and MCF-7 (human breast cancer), with IC(50)s ranging from 2.37 to 4.12 mu M while other metabolites exhibited no cytotoxic activity up to a concentration of 5.0 mu M. |
| WOS关键词 | ASPERGILLUS ; MYCOSPHAERELLA ; DIVERSITY ; PLANT |
| 资助项目 | National Institutes of Health[R01 CA090625] ; National Institutes of Health[P41 GM094060] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000589391000001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292653]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Gunatilaka, A. A. Leslie |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Univ Arizona, Coll Agr & Life Sci, Sch Plant Sci, Tucson, AZ 85721 USA 3.Univ Arizona, Coll Agr & Life Sci, Southwest Ctr Nat Prod Res, Sch Nat Resources & Environm, 250 E,Valencia Rd, Tucson, AZ 85706 USA |
| 推荐引用方式 GB/T 7714 | Xu, Ya-Ming,Arnold, A. Elizabeth,U'Ren, Jana M.,et al. Teratopyrones A-C, Dimeric Naphtho-gamma-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense[J]. MOLECULES,2020,25(21):10. |
| APA | Xu, Ya-Ming,Arnold, A. Elizabeth,U'Ren, Jana M.,Xuan, Li-Jiang,Wang, Wen-Qiong,&Gunatilaka, A. A. Leslie.(2020).Teratopyrones A-C, Dimeric Naphtho-gamma-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense.MOLECULES,25(21),10. |
| MLA | Xu, Ya-Ming,et al."Teratopyrones A-C, Dimeric Naphtho-gamma-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense".MOLECULES 25.21(2020):10. |
入库方式： OAI收割
来源：上海药物研究所
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