中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans

文献类型:期刊论文

作者Ma, Jiang3,4; Zhang, Wei2; He, Yisheng3,4; Zhu, Lin3,4; Zhang, Chunyuan3,4; Liu, Jia1,3; Ye, Yang1,3; Zhuge, Yuzheng2; Lin, Ge3,4
刊名ARCHIVES OF TOXICOLOGY
出版日期2020-11-18
页码7
ISSN号0340-5761
关键词Pyrrolizidine alkaloids Liver injury Diagnostic biomarkers Pyrrole-hemoglobin adducts Pyrrole-plasma protein adducts
DOI10.1007/s00204-020-02947-4
通讯作者Zhuge, Yuzheng(yuzheng9111963@aliyun.com) ; Lin, Ge(linge@cuhk.edu.hk)
英文摘要Pyrrolizidine alkaloids (PAs) are naturally occurring hepatotoxins widely present in hundreds of plant species and also known to contaminate many foodstuffs, such as grain, honey, and tea. The formation of pyrrole-protein adducts via metabolic activation of PAs has been suggested as a primary trigger initiating hepatotoxicity. The present study for the first time tested the suitability of pyrrole-hemoglobin adducts as a novel and specific biomarker of PA exposure in humans. The level and elimination kinetics of pyrrole-hemoglobin adducts were systematically investigated in the blood samples of 43 PA-induced liver injury (PA-ILI) patients. The results revealed significantly higher concentrations (84.50 +/- 78.38 nM) and longer persistence (similar to 4 months) of pyrrole-hemoglobin adducts than that (concentration: 9.53 +/- 10.72 nM; persistence: similar to 2 months) of pyrrole-plasma protein adducts, our previously developed PA exposure biomarker. Our findings confirmed that pyrrole-hemoglobin adducts with higher level and longer persistence should serve as a more applicable PA exposure biomarker for future clinical diagnosis of PA-ILI in drug/herb-induced liver injury patients.
WOS关键词PROTEIN ADDUCTS ; METABOLIC-ACTIVATION ; ALBUMIN ADDUCTS ; LIVER TOXICITY ; STABILITY ; OXIDE ; FOOD
资助项目Research Grants Council of Hong Kong[14111816] ; Research Grants Council of Hong Kong[14106318] ; Chinese University of Hong Kong[4054503]
WOS研究方向Toxicology
语种英语
出版者SPRINGER HEIDELBERG
WOS记录号WOS:000590483200001
源URL[http://119.78.100.183/handle/2S10ELR8/292665]  
专题新药研究国家重点实验室
通讯作者Zhuge, Yuzheng; Lin, Ge
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
2.Nanjing Univ, Sch Med, Drum Tower Hosp, Dept Gastroenterol, Nanjing, Peoples R China
3.Chinese Acad Sci, Joint Res Lab Promoting Globalizat Tradit Chinese, Shanghai, Peoples R China
4.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Ma, Jiang,Zhang, Wei,He, Yisheng,et al. Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans[J]. ARCHIVES OF TOXICOLOGY,2020:7.
APA Ma, Jiang.,Zhang, Wei.,He, Yisheng.,Zhu, Lin.,Zhang, Chunyuan.,...&Lin, Ge.(2020).Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans.ARCHIVES OF TOXICOLOGY,7.
MLA Ma, Jiang,et al."Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans".ARCHIVES OF TOXICOLOGY (2020):7.

入库方式: OAI收割

来源:上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。