Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents
文献类型：期刊论文
| 作者 | Xiao YouAn3; Wang ZhiQiang2; Wang XueMin2; Hui Yi2; Ling Yong2; Wang XinYang2; He LiQin3 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2013 |
| 卷号 | 24期号:8页码:727 |
| 关键词 | Synthesis 2-Aminoimidazolone Anti-tumor agents Cytotoxic activities Cell apoptosis |
| ISSN号 | 1001-8417 |
| 英文摘要 | Novel 2-aminoimidazolone derivatives were synthesized. Most compounds displayed strong anticancer activities against human carcinoma cells in vitro. Compounds 8a, 8b and 8j exhibited optimal activity superior to 5-FU in most cancer cells tested. Especially, the IC(50)s of 8b (12.6-21.5 mu mol/L) against five tumor cells were 1-4 fold less than those of 5-FU (18.4-56.1 mu mol/L) in vitro. Furthermore, compound 8b could induce SMMC-7721 cell apoptosis in a dose-dependent manner. Therefore, our novel findings may provide a new framework for the design of new 2-aminoimidazolone derivatives for the treatment of cancer. (C) 2013 Li-Qin He and Yong Ling. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 资助项目 | [Nature and Science Foundation of Department of Education, Anhui province] ; [Applied Research Projects of Nantong City] ; [Priority Academic Programs Development of Jiangsu Higher Education Institutions (PAPD)] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292704]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.南通大学 3.Anhui Univ Tradit Chinese Med, Anhui Key Lab Modernized Chinese Materials Med, Hefei 230031, Peoples R China Anhui Key Lab Modernized Chinese Materials Med |
| 推荐引用方式 GB/T 7714 | Xiao YouAn,Wang ZhiQiang,Wang XueMin,et al. Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents[J]. CHINESE CHEMICAL LETTERS,2013,24(8):727. |
| APA | Xiao YouAn.,Wang ZhiQiang.,Wang XueMin.,Hui Yi.,Ling Yong.,...&He LiQin.(2013).Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents.CHINESE CHEMICAL LETTERS,24(8),727. |
| MLA | Xiao YouAn,et al."Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents".CHINESE CHEMICAL LETTERS 24.8(2013):727. |
入库方式： OAI收割
来源：上海药物研究所
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