Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus
文献类型：期刊论文
| 作者 | Liu Zhenjia5; Yang Yanjuan4; Jiang Lei5; Xu Yingchun3; Wang Aixia2; Du Guanhua1; Gao Jinming5 |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:8页码:1038 |
| 关键词 | CHEMOKINE RECEPTORS LIGAND-BINDING ANAPHYLATOXIN RECOGNITION RESIDUES C5L2 Staphylococcus aureus chemotaxis inhibitory protein tyrosine sulfation post-translational modification chemotactic receptor C5aR |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: Staphylococcus aureus evades host defense through releasing several virulence proteins, such as chemotaxis inhibitory protein of staphylococcus aureus (CHIPS). It has been shown that extracellular N terminus of C5a receptor (C5aR) forms the binding domain for CHIPS, and tyrosine sulfation is emerging as a key factor in determining protein-protein interaction. The aim of this study was to evaluate the role of tyrosine sulfation of N-terminal of C5aR in its binding with CHIPS. |
| 资助项目 | [National Natural Science Foundation of China] ; [Beijing Natural Sciences Foundation] ; [Education Ministry of China New Century Excellent Talent] ; [Janssen Research Council China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292742]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.Beijing Union Med Coll Hosp, Peking Union Med Coll, Department Infect Dis, Beijing 100730, Peoples R China 3.Beijing Union Med Coll Hosp, Peking Union Med Coll, Department Med Microbiol, Beijing 100730, Peoples R China 4.Ningxia Med University, Dept Resp Dis, Affiliated Hosp, Yinchuan 750004, Peoples R China 5.Beijing Union Med Coll Hosp, Peking Union Med Coll, Department Resp Dis, Beijing 100730, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Zhenjia,Yang Yanjuan,Jiang Lei,et al. Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus[J]. ACTA PHARMACOLOGICA SINICA,2011,32(8):1038. |
| APA | Liu Zhenjia.,Yang Yanjuan.,Jiang Lei.,Xu Yingchun.,Wang Aixia.,...&Gao Jinming.(2011).Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus.ACTA PHARMACOLOGICA SINICA,32(8),1038. |
| MLA | Liu Zhenjia,et al."Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus".ACTA PHARMACOLOGICA SINICA 32.8(2011):1038. |
入库方式： OAI收割
来源：上海药物研究所
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