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W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway

文献类型：期刊论文

作者Ll Ting3; Lin Guangyao2; Zhong Li3; Zhou Yan3; Wang Jia3; Zhu Yue3; Feng Yang3; Cai Xiaoqing3; Liu Qing3; Nosjean Olivier1
刊名Acta Pharmacologica Sinica
出版日期2017
卷号38期号:7页码:1022
关键词diabetes glucose TXNIP p-cells W2476 high-throughput screening
ISSN号1671-4083
英文摘要Recent evidence shows that high glucose levels recruit carbohydrate response element-binding protein, which binds the promoter of thioredoxin-interacting protein (txnip), thereby regulating its expression in β-cells. Overexpression of txnip not only induces β-cell apoptosis but also reduces insulin production. Thus, the discovery of compounds that either inhibit TXNIP activity or suppress its expression was the focus of the present study. INS-1E cells stably transfected with either a txnip proximal glucose response element connected to a luciferase reporter plasmid (BG73) or full-length txnip promoter connected to a luciferase reporter plasmid (CL108) were used in primary and secondary high-throughput screening campaigns, respectively. From 256 000 synthetic compounds, a small molecule compound, W2476 9-((1-(4-acetyl-phenyloxy)-ethyl)-2-)adenine
语种英语
源URL[http://119.78.100.183/handle/2S10ELR8/292778]  
专题中国科学院上海药物研究所
作者单位1.Pole d'Expertise Biotechnologie, Chimie et Biologie, Institut de Recherches SERVIER
2.中国科学院大学
3.中国科学院上海药物研究所
推荐引用方式
GB/T 7714		 Ll Ting,Lin Guangyao,Zhong Li,et al. W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway[J]. Acta Pharmacologica Sinica,2017,38(7):1022.
APA Ll Ting.,Lin Guangyao.,Zhong Li.,Zhou Yan.,Wang Jia.,...&Wang Mingwei.(2017).W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway.Acta Pharmacologica Sinica,38(7),1022.
MLA Ll Ting,et al."W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway".Acta Pharmacologica Sinica 38.7(2017):1022.

入库方式： OAI收割

来源：上海药物研究所

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