Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells
文献类型：期刊论文
| 作者 | Qinghao Jin4; Jianqing Zhang4; Jinjun Hou4 ; Min Lei4; Chen Liu4; Xia Wang4; Yong Huang4; Shuai Yao4; Bang Yeon Hwang1; Wanying Wu4
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| 刊名 | 药学学报:英文版
 |
| 出版日期 | 2019 |
| 卷号 | 000期号:004页码:809 |
| 关键词 | Alisma plantago-aquatica Linn. Protostane-type triterpenoids Caco-2 cells LPS-induced NO production |
| ISSN号 | 2211-3835 |
| 英文摘要 | Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds(1 e9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A-F(1 e6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H(8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I(9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4-6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76 e38.20 mmol/L. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/293205]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.College of Pharmacy,Chungbuk National University,South Korea 2.中国科学院大学 3.School of Pharmacy,Shenyang Pharmaceutical University 4.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Qinghao Jin,Jianqing Zhang,Jinjun Hou,et al. Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells[J]. 药学学报:英文版,2019,000(004):809. |
| APA | Qinghao Jin.,Jianqing Zhang.,Jinjun Hou.,Min Lei.,Chen Liu.,...&Dean Guo.(2019).Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells.药学学报:英文版,000(004),809. |
| MLA | Qinghao Jin,et al."Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells".药学学报:英文版 000.004(2019):809. |
入库方式： OAI收割
来源：上海药物研究所
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