Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities
文献类型：期刊论文
| 作者 | Gao Na; Shang ZhiChun; Yu Pei; Luo Jie; Jian KaiLi; Kong LingYi; Yang MingHua |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2017 |
| 卷号 | 28期号:6页码:1194 |
| 关键词 | MARINE-DERIVED FUNGUS DIKETOPIPERAZINE ALKALOIDS CONFORMATIONAL-ANALYSIS FILAMENTOUS FUNGI BIOSYNTHESIS ASPERGILLUS APOPTOSIS DIFFERENTIATION ELUCIDATION MYCOTOXINS Penicillium brefeldianum Alkaloids Indoloditerpene Indole-diketopiperazine 13-Membered macrolide Cytotoxicities |
| ISSN号 | 1001-8417 |
| 英文摘要 | One new indoloditerpene, 6,7-dehydropaxilline (1), one new indole-diketopiperazine, spirotryprostatin F (2), and one new 13-membered macrolide, N-demethylmelearoride A (3), as well as 8 known alkaloids (4-11), were isolated from the solid cultures of the endophytic fungus, Penicillium brefeldianum. The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism (CD) exciton chirality method. All the metablites were evaluated for their cytotoxic activites against three human tumor cell lines. Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC50 values of 14.1 mu mol/1, and 35.5 mu mol/L, respectively. Compound 3 showed moderate activity against HepG2 cells with IC50 values of 36.6 mu mol/L. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 资助项目 | [National Natural Science Foundation of China] ; [Program for Changjiang Scholars and Innovative Research Team in University] ; [Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)] ; [Fundamental Research Funds for the Central Universities] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/293221]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Gao Na,Shang ZhiChun,Yu Pei,et al. Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities[J]. CHINESE CHEMICAL LETTERS,2017,28(6):1194. |
| APA | Gao Na.,Shang ZhiChun.,Yu Pei.,Luo Jie.,Jian KaiLi.,...&Yang MingHua.(2017).Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities.CHINESE CHEMICAL LETTERS,28(6),1194. |
| MLA | Gao Na,et al."Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities".CHINESE CHEMICAL LETTERS 28.6(2017):1194. |
入库方式： OAI收割
来源：上海药物研究所
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