Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry~1
文献类型：期刊论文
| 作者 | Xiaofen LI; Yiping WANG
|
| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2007 |
| 卷号 | 28期号:6页码:789 |
| 关键词 | lithospermate B myocardial microperfu-sion laser Doppler flowmetry cardiac output ultrasonic Doppler flowmetry |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: To investigate the effects of depside salts from Salvia miltiorrhiza on myocardial microperfusion and systemic hemodynamics in open-chest anaesthetized Sprague-Dawley rats. Methods: Myocardial microperfusion was measured by laser Doppler flowmetry with a needle probe; cardiac output (CO) was determined using ultrasonic Doppler flowmetry. Other hemodynamic parameters, including femoral artery blood pressure, cardiac inotropy, and systemic vascular resistance (SVR) were simultaneously recorded by the PowerLab system. Results: Intravenous administration of S miltiorrhiza depside salts resulted in a significant immediate increase in CO and cardiac inotropy, but a fall in SVR. S miltiorrhiza depside salts (30 mg/kg and 60 mg/kg) promoted cardiac index (CI) by 12.2%±6.3% (P<0.01 vs baseline) and 20.1%±3.5% (P<0.01), respectively. Myocardial microperfusion maxi mally i n cr eased by 6.3%±2.9% (P<0.01) an d 9.6%±4.0% (P<0.01) for 30 mg/kg and 60 mg/kg S miltiorrhiza depside salts, respectively. Conclusion: These results indicated that S miltiorrhiza depside salts improved myocardial micro-perfusion, as well as CO. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/293229]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Xiaofen LI,Yiping WANG. Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry~1[J]. Acta Pharmacologica Sinica,2007,28(6):789. |
| APA | Xiaofen LI,&Yiping WANG.(2007).Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry~1.Acta Pharmacologica Sinica,28(6),789. |
| MLA | Xiaofen LI,et al."Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry~1".Acta Pharmacologica Sinica 28.6(2007):789. |
入库方式： OAI收割
来源：上海药物研究所
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