Synthesis and Evaluation of 8-^131IIodo-substituted Imidazopyridine Derivative as Single Photon Emission Computed Tomography Tracer for Peripheral Benzodiazepine Receptors
文献类型：期刊论文
| 作者 | Li Bin2; Li Jianfeng1 ; Sun Xiaoguang2; Huang Gang2
|
| 刊名 | 中国化学快报：英文版
 |
| 出版日期 | 2006 |
| 卷号 | 17.0期号:011页码:1435 |
| 关键词 | 吡啶乙酰胺 咪唑 镇静药 感受器 合成方法 |
| ISSN号 | 1001-8417 |
| 英文摘要 | A novel N-methyl, N-phenyl-6-chloro-2-（4-chlorophenyl）-8-iodoimidazo1, 2-a- pyridine-3-ylacetamide （compound Ⅴ） was synthesized, radiolabelled with 131I and evaluated in vitro. In vitro cell uptake studies showed that MDA-MB-231 cells yield four-fold higher specific uptake of ^131I-compound Ⅵ than MCF-7 cells, corresponding to the increased expression of PBR in MDA-MB-231 cells. Blocking studies significantly reduced the MDA-MB-231 cells uptake of ^131I-compound Ⅵ. It indicated that ^131I-compound Ⅵ might be a potential SPECT radioligand for imaging of PBR. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/293265]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.Department of Nuclear Medicine, Reiji Hospital, Medical School of Shanghai Jiaotong University |
| 推荐引用方式 GB/T 7714 | Li Bin,Li Jianfeng,Sun Xiaoguang,et al. Synthesis and Evaluation of 8-^131IIodo-substituted Imidazopyridine Derivative as Single Photon Emission Computed Tomography Tracer for Peripheral Benzodiazepine Receptors[J]. 中国化学快报：英文版,2006,17.0(011):1435. |
| APA | Li Bin,Li Jianfeng,Sun Xiaoguang,&Huang Gang.(2006).Synthesis and Evaluation of 8-^131IIodo-substituted Imidazopyridine Derivative as Single Photon Emission Computed Tomography Tracer for Peripheral Benzodiazepine Receptors.中国化学快报：英文版,17.0(011),1435. |
| MLA | Li Bin,et al."Synthesis and Evaluation of 8-^131IIodo-substituted Imidazopyridine Derivative as Single Photon Emission Computed Tomography Tracer for Peripheral Benzodiazepine Receptors".中国化学快报：英文版 17.0.011(2006):1435. |
入库方式： OAI收割
来源：上海药物研究所
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