Novel C-17 spirost protostane-type triterpenoids from Alismaplantago-aquaticawith anti-inflammatory activity inCaco-2cells
文献类型：期刊论文
| 作者 | Qinghao Jin4; Jianqing Zhang4; Jinjun Hou4 ; Min Lei4; Chen Liu4; Xia Wang4; Yong Huang4; Shuai Yao4; Bang Yeon Hwang1; Wanying Wu4
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| 刊名 | Acta Pharmaceutica Sinica B
 |
| 出版日期 | 2019 |
| 卷号 | 9期号:4页码:809 |
| 关键词 | Therapeutics. Pharmacology RM1-950 |
| ISSN号 | 2211-3835 |
| 英文摘要 | Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds (1–9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A?F (1–6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H (8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I (9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4?6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76–38.20μmol/L. Key words: Alisma plantago-aquatica Linn., Protostane-type triterpenoids, Caco-2cells, LPS-induced NO production |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/293374]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.College of Pharmacy 2.中国科学院大学 3.School of Pharmacy 4.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Qinghao Jin,Jianqing Zhang,Jinjun Hou,et al. Novel C-17 spirost protostane-type triterpenoids from Alismaplantago-aquaticawith anti-inflammatory activity inCaco-2cells[J]. Acta Pharmaceutica Sinica B,2019,9(4):809. |
| APA | Qinghao Jin.,Jianqing Zhang.,Jinjun Hou.,Min Lei.,Chen Liu.,...&Dean Guo.(2019).Novel C-17 spirost protostane-type triterpenoids from Alismaplantago-aquaticawith anti-inflammatory activity inCaco-2cells.Acta Pharmaceutica Sinica B,9(4),809. |
| MLA | Qinghao Jin,et al."Novel C-17 spirost protostane-type triterpenoids from Alismaplantago-aquaticawith anti-inflammatory activity inCaco-2cells".Acta Pharmaceutica Sinica B 9.4(2019):809. |
入库方式： OAI收割
来源：上海药物研究所
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