Chemical profile of the active fraction of Yi-Gan San by HPLC-DAD-Q-TOF-MS and its neuroprotective effect against glutamate-induced cytotoxicity
文献类型：期刊论文
| 作者 | Chen Han2; Shi YuanYuan2; Wei MengLin2; Liu WenYuan2; Feng Feng1 |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2014 |
| 卷号 | 12期号:11页码:869 |
| 关键词 | FLIGHT MASS-SPECTROMETRY CHLOROGENIC ACIDS ARRAY DETECTION GENUS UNCARIA LC-MS IDENTIFICATION ANTIOXIDANT YOKUKANSAN ALKALOIDS LICORICE Yi-Gan San active fraction Chemical constituents Simultaneous quantification HPLC-DAD-QTOF-MS |
| ISSN号 | 2095-6975 |
| 英文摘要 | Yi-Gan San (YGS), a traditional Chinese medicine for dementia-related symptoms, was previously fractionated. One active fraction, YGS40 exhibited a neuroprotective effect against glutamate-induced cytotoxicity. In the present study, high-performance liquid chromatography, coupled with diode-array detection and quadrupole time-of-flight mass spectrometry, was applied for the identification of its chemical constituents and for quantification studies. The chemical profile of YGS40 consisted of sixty-four identified or tentatively characterized compounds. The levels of the major marker compounds increased significantly in the mixed decoction compared with those in the single plant decoction. The results suggest the high precision of the analyses of most of the constituents in YGS40 and establish the quantitative variations of the major marker compounds between the single and mixed decoction processes. |
| 资助项目 | [National Natural Science Foundation of China] ; [Priority Academic Program Development of Jiangsu Higher Education Institutions] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/293557]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.中国科学院南京地理与湖泊研究所 |
| 推荐引用方式 GB/T 7714 | Chen Han,Shi YuanYuan,Wei MengLin,et al. Chemical profile of the active fraction of Yi-Gan San by HPLC-DAD-Q-TOF-MS and its neuroprotective effect against glutamate-induced cytotoxicity[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2014,12(11):869. |
| APA | Chen Han,Shi YuanYuan,Wei MengLin,Liu WenYuan,&Feng Feng.(2014).Chemical profile of the active fraction of Yi-Gan San by HPLC-DAD-Q-TOF-MS and its neuroprotective effect against glutamate-induced cytotoxicity.CHINESE JOURNAL OF NATURAL MEDICINES,12(11),869. |
| MLA | Chen Han,et al."Chemical profile of the active fraction of Yi-Gan San by HPLC-DAD-Q-TOF-MS and its neuroprotective effect against glutamate-induced cytotoxicity".CHINESE JOURNAL OF NATURAL MEDICINES 12.11(2014):869. |
入库方式： OAI收割
来源：上海药物研究所
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