Gene expression pattern in apoptotic QGY-7703 cells induced by homoharringtonine~1
文献类型：期刊论文
| 作者 | Wei JIN3; Lefeng QU2; Qin CHEN1; Xinzhong CHANG3; Jiong WU3; Zhimin SHAO3 |
| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2007 |
| 卷号 | 28期号:6页码:859 |
| 关键词 | QGY-7703 cells homoharringtonine apoptosis gene expression |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: To classify the genes responsible for apoptosis in QGY-7703 cells induced by homoharringtonine (HHT). Methods: Apoptosis in QGY-7703 cells induced by HHT was demonstrated by DNA fragmentation and morphological observation. cDNA microarray technology was used to detect gene transcription, and the result of microarrays for genes was confirmed by RT-PCR. Results: Seventy-eight individual mRNA were identified and their transcription levels changed significantly. Those genes, of which 68% were upregulated and 32% were downregulated, were partially related to apoptosis. They were mostly oncogenes, tumor suppressors, enzymes, and kinases. Conclusion: HHT is a potential drug in the treatment of liver cancer. TGF-β, TNF, FAS, p38 MAP K, and p53 apoptosis signaling pathways were activated during apoptosis in QGY-7703 cells. Such inducible genes may play important roles in apoptosis and deserve to be further studied. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/293682]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.Department of Vascular Surgery and Institute of Vascular Surgery of PLA, Changhai Hospital 3.复旦大学 |
| 推荐引用方式 GB/T 7714 | Wei JIN,Lefeng QU,Qin CHEN,et al. Gene expression pattern in apoptotic QGY-7703 cells induced by homoharringtonine~1[J]. Acta Pharmacologica Sinica,2007,28(6):859. |
| APA | Wei JIN,Lefeng QU,Qin CHEN,Xinzhong CHANG,Jiong WU,&Zhimin SHAO.(2007).Gene expression pattern in apoptotic QGY-7703 cells induced by homoharringtonine~1.Acta Pharmacologica Sinica,28(6),859. |
| MLA | Wei JIN,et al."Gene expression pattern in apoptotic QGY-7703 cells induced by homoharringtonine~1".Acta Pharmacologica Sinica 28.6(2007):859. |
入库方式： OAI收割
来源：上海药物研究所
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