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Discovery and structural optimization of 4-(4-(benzyloxy) phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists

文献类型：期刊论文

作者Wu Xishan4; Wang Rui3; Xing Yanli3; Xue Xiaoqian3; Zhang Yan3; Lu Yongzhi3; Song Yu3; Luo Xiaoyu3; Wu Chun3; Zhou Yulai1
刊名ACTA PHARMACOLOGICA SINICA
出版日期2016
卷号37期号:11页码:1516
关键词GAMMA-T ORPHAN RECEPTORS CELL-DIFFERENTIATION LIGAND IDENTIFICATION MODULATORS DERIVATIVES PROTEIN INHIBITORS DOCKING nuclear receptor RORc inverse agonist SAR structure-based optimization autoimmune disease
ISSN号1671-4083
英文摘要Aim: Retinoic acid receptor-related orphan nuclear receptors (RORs) are orphan nuclear receptors that show constitutive activity in the absence of ligands. Among 3 subtypes of RORs, RORc is a promising therapeutic target for the treatment of Th17-mediated autoimmune diseases. Here, we report novel RORc inverse agonists discovered through structure-based drug design.
资助项目[National Natural Science Foundation of China] ; ["100 Talents Project" of Chinese Academy of Sciences] ; [Natural Science Foundation of Guangdong Province] ; [Guangzhou Healthcare Collaborative Innovation Programs] ; [Chinese Academy of Sciences Cloud Platform for Stem Cell and Biomedical Research] ; [National Key Basic Research Program of China (973 Program)] ; [Bureau of Science and Information Technology of Guangzhou Municipality] ; [Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences]
语种英语
源URL[http://119.78.100.183/handle/2S10ELR8/293849]  
专题中国科学院上海药物研究所
作者单位1.吉林大学
2.中国科学院大学
3.中国科学院
4.中国科学院上海药物研究所
推荐引用方式
GB/T 7714		 Wu Xishan,Wang Rui,Xing Yanli,et al. Discovery and structural optimization of 4-(4-(benzyloxy) phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists[J]. ACTA PHARMACOLOGICA SINICA,2016,37(11):1516.
APA Wu Xishan.,Wang Rui.,Xing Yanli.,Xue Xiaoqian.,Zhang Yan.,...&Xu Yong.(2016).Discovery and structural optimization of 4-(4-(benzyloxy) phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists.ACTA PHARMACOLOGICA SINICA,37(11),1516.
MLA Wu Xishan,et al."Discovery and structural optimization of 4-(4-(benzyloxy) phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists".ACTA PHARMACOLOGICA SINICA 37.11(2016):1516.

入库方式： OAI收割

来源：上海药物研究所

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