Timosaponin derivative YY-23 acts as a non- competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice
文献类型：期刊论文
| 作者 | QiZHANG; Fei GUO; Zhi-wen FU; Bing ZHANG; Cheng-gang HUANG ; Yang LI
|
| 刊名 | 中国药理学报：英文版
 |
| 出版日期 | 2016 |
| 卷号 | 000期号:002页码:166 |
| 关键词 | 药理 药学 处方 制剂 |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim： N-methyI-D-aspartic acid （NMDA） receptor modulators have shown promising results as potential antidepressant agents, whereas timosaponins extracted from the Chinese herb Rhizoma Anemarrhenae exhibit antidepressant activities. In the present study we examined whether YY-23, a modified metabolite of timosaponin B-Ⅲ, could affect NMDA receptors in rat hippocampal neurons in vitro, and evaluated its antidepressant-like effects in stressed mice. Methods： NMDA-induced currents were recorded in acutely dissociated rat hippocampal CA1 neurons using a whole-cell recording technique. C57BL/6 mice were exposed to a 6-week chronic mild stress （CMS） or a 10-d chronic social defeat stress （CSDS）. The stressed mice were treated with YY-23 （20 mg.kg-1.d-1） or a positive-control drug, fluoxetine （10 mg.kg-l.d-1） for 3 weeks. Behavioral assessments were carried out every week. Results： In acutely dissociated rat hippocampal CA1 neurons, YY-23 selectively and reversibly inhibited NMDA-induced currents with an EC50 value of 2.8 pmol/L. This inhibition of NMDA-induced currents by YY-23 was non-competitive, and had no features of voltage- dependency or use-dependency. Treatment of the stressed mice with YY-23 not only reversed CMS-induced deficiency of sucrose preference and immobility time, and CSDS-induced reduction of social interaction, but also had faster onset as compared to fluoxetine Conclusion： YY-23 is a novel non-competitive antagonist of NMDA receptors with promising rapid antidepressant-like effects in mouse models of CMS and CSDS depression. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/293915]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | QiZHANG,Fei GUO,Zhi-wen FU,et al. Timosaponin derivative YY-23 acts as a non- competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice[J]. 中国药理学报：英文版,2016,000(002):166. |
| APA | QiZHANG,Fei GUO,Zhi-wen FU,Bing ZHANG,Cheng-gang HUANG,&Yang LI.(2016).Timosaponin derivative YY-23 acts as a non- competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice.中国药理学报：英文版,000(002),166. |
| MLA | QiZHANG,et al."Timosaponin derivative YY-23 acts as a non- competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice".中国药理学报：英文版 000.002(2016):166. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。