Advances in development of fluorescent probes for detecting amyloid-β aggregates
文献类型：期刊论文
| 作者 | Xu Mingming; Ren Wenming; Tang Xican ; Hu Youhong; Zhang Haiyan
|
| 刊名 | 中国药理学报：英文版
 |
| 出版日期 | 2016 |
| 卷号 | 000期号:006页码:719 |
| 关键词 | 荧光探针 β淀粉样蛋白 聚集体 β-淀粉样蛋白 阿尔茨海默病 早期诊断 生物标志物 转基因小鼠 |
| ISSN号 | 1671-4083 |
| 英文摘要 | With accumulating evidence suggesting that amyloid-β （Aβ） deposition is a good diagnostic biomarker for Alzheimer＇s disease （AD）, the discovery of active Aβ probes has become an active area of research. Among the existing imaging methods, optical imaging targeting Aβ aggregates （fibrils or oligomers）, especially using near-infrared （NIR） fluorescent probes, is increasingly recognized as a promising approach for the early diagnosis of AD due to its real time detection, low cost, lack of radioactive exposure and high-resolution. In the past decade, a variety of fluorescent probes have been developed and tested for efficiency in vitro, and several probes have shown efficacy in AD transgenic mice. This review classifies these representative probes based on their chemical structures and functional modes （dominant solvent-dependent mode and a novel solvent-independent mode）. Moreover, the pharmaceutical characteristics of these representative probes are summarized and discussed. This review provides important perspectives for the future development of novel NIR Aβ diagnostic probes. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/293984]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Xu Mingming,Ren Wenming,Tang Xican,et al. Advances in development of fluorescent probes for detecting amyloid-β aggregates[J]. 中国药理学报：英文版,2016,000(006):719. |
| APA | Xu Mingming,Ren Wenming,Tang Xican,Hu Youhong,&Zhang Haiyan.(2016).Advances in development of fluorescent probes for detecting amyloid-β aggregates.中国药理学报：英文版,000(006),719. |
| MLA | Xu Mingming,et al."Advances in development of fluorescent probes for detecting amyloid-β aggregates".中国药理学报：英文版 000.006(2016):719. |
入库方式： OAI收割
来源：上海药物研究所
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