A network pharmacology study of Sendeng-4, a Mongolian medicine
文献类型：期刊论文
| 作者 | Tian Zi; Dong Yu |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2015 |
| 卷号 | 13期号:2页码:108 |
| 关键词 | TRADITIONAL CHINESE MEDICINE DRUG DISCOVERY HERBAL FORMULAS CYTOSCAPE DATABASE TARGET DISEASE Network pharmacology Mongolian medicine Sendeng-4 Drug targeting Disease pathway networks Rheumatoid arthritis In vivo evaluation |
| ISSN号 | 2095-6975 |
| 英文摘要 | We collected the data on the Sendeng-4 chemical composition corresponding targets through the literature and from DrugBank, SuperTarget, TTD (Therapeutic Targets Database) and other databases and the relevant signaling pathways from the KEGG (Kyoto Encyclopedia of Genes and Genomes) database and established models of the chemical composition-target network and chemical composition-target- disease network using Cytoscape software, the analysis indicated that the chemical composition had at least nine different types of targets that acted together to exert effects on the diseases, suggesting a "multi-component, multi-target" feature of the traditional Mongolian medicine: We also employed the rat model of rheumatoid arthritis induced by Collgen Type II to validate the key targets of the chemical components of Sendeng-4, and three of the key targets were validated through laboratory experiments, further confirming the anti-inflammatory effects of Sendeng-4. In all, this study predicted the active ingredients and targets of Sendeng-4, and explored its mechanism of action, which provided new strategies and methods for further research and development of Sendeng-4 and other traditional Mongolian medicines as well. |
| 资助项目 | [National Natural Science Foundation of China] ; [Inner Mongolia Natural Science Foundation] ; [Science and Technology Project of social development in Inner Mongolia] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294142]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Tian Zi,Dong Yu. A network pharmacology study of Sendeng-4, a Mongolian medicine[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2015,13(2):108. |
| APA | Tian Zi,&Dong Yu.(2015).A network pharmacology study of Sendeng-4, a Mongolian medicine.CHINESE JOURNAL OF NATURAL MEDICINES,13(2),108. |
| MLA | Tian Zi,et al."A network pharmacology study of Sendeng-4, a Mongolian medicine".CHINESE JOURNAL OF NATURAL MEDICINES 13.2(2015):108. |
入库方式： OAI收割
来源：上海药物研究所
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