Reversal of multidrug resistance by icaritin in doxorubicin-resistant human osteosarcoma cells
文献类型：期刊论文
| 作者 | Wang ZhenDong; Wang RuiZhi; Xia YuanZheng; Kong LingYi; Yang Lei |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2018 |
| 卷号 | 16期号:1页码:20 |
| 关键词 | CHEMOTHERAPEUTIC-AGENTS HERBA-EPIMEDII CANCER-CELLS TRANSPORTERS EXPRESSION FLAVONOIDS PROTEIN-1 ABCB1 PHARMACOKINETICS PROLIFERATION Osteosarcoma Icaritin Multidrug resistance MDR1 MRP1 |
| ISSN号 | 2095-6975 |
| 英文摘要 | Multidrug resistance (MDR) is one of the major obstacles in cancer chemotherapy. Our previous study has shown that icariin could reverse MDR in MG-63 doxorubicin-resistant (MG-63/DOX) cells. It is reported that icariin is usually metabolized to icariside II and icaritin. Herein, we investigated the effects of icariin, icariside II, and icaritin (ICT) on reversing MDR in MG-63/DOX cells. Among these compounds, ICT exhibited strongest effect and showed no obvious cytotoxicity effect on both MG-63 and MG-63/DOX cells ranging from 1 to 10 mu mol.L-1. Furthermore, ICT increased accumulation of rhodamine 123 and 6-carboxyfluorescein diacetate and enhanced DOX-induced apoptosis in MG-63/DOX cells in a dose-dependent manner. Further studies demonstrated that ICT decreased the mRNA and protein levels of multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 1 (MRP1). We also verified that blockade of STAT3 phosphorylation was involved in the reversal effect of multidrug resistance in MG-63/DOX cells. Taken together, these results indicated that ICT may be a potential candidate in chemotherapy for osteosarcoma. |
| 资助项目 | [National Natural Science Foundation of China] ; [Natural Science Foundation of Jiangsu Province] ; [Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)] ; [Program for Changjiang Scholars and Innovative Research Team in University] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294171]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Wang ZhenDong,Wang RuiZhi,Xia YuanZheng,et al. Reversal of multidrug resistance by icaritin in doxorubicin-resistant human osteosarcoma cells[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2018,16(1):20. |
| APA | Wang ZhenDong,Wang RuiZhi,Xia YuanZheng,Kong LingYi,&Yang Lei.(2018).Reversal of multidrug resistance by icaritin in doxorubicin-resistant human osteosarcoma cells.CHINESE JOURNAL OF NATURAL MEDICINES,16(1),20. |
| MLA | Wang ZhenDong,et al."Reversal of multidrug resistance by icaritin in doxorubicin-resistant human osteosarcoma cells".CHINESE JOURNAL OF NATURAL MEDICINES 16.1(2018):20. |
入库方式： OAI收割
来源：上海药物研究所
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