Dynamic modifications of biomacromolecules:mechanism and chemical interventions
文献类型：期刊论文
| 作者 | Chu Wang7; Peng Zou7; Caiguang Yang6 ; Lei Liu5; Liang Cheng4; Xiaopeng He3; Liang Zhang2; Yan Zhang1; Hualiang Jiang6; Peng RChen7
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| 刊名 | 中国科学:生命科学英文版
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| 出版日期 | 2019 |
| 卷号 | 62.0期号:011页码:1459 |
| 关键词 | chemical biology biomacromolecule dynamic modification modification analysis chemical intervention |
| ISSN号 | 1674-7305 |
| 英文摘要 | Biological macromolecules(proteins,nucleic acids,polysaccharides,etc.)are the building blocks of life,which constantly undergo chemical modifications that are often reversible and spatial-temporally regulated.These dynamic properties of chemical modifications play fundamental roles in physiological processes as well as pathological changes of living systems.The Major Research Project(MRP)funded by the National Natural Science Foundation of China(NSFC)—"Dynamic modifications of biomacromolecules:mechanism and chemical interventions"aims to integrate cross-disciplinary approaches at the interface of chemistry,life sciences,medicine,mathematics,material science and information science with the following goals:(i)developing specific labeling techniques and detection methods for dynamic chemical modifications of biomacromolecules,(ii)analyzing the molecular mechanisms and functional relationships of dynamic chemical modifications of biomacromolecules,and(iii)exploring biomacromolecules and small molecule probes as potential drug targets and lead compounds. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294229]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.National Natural Science Foundation of China 2.Department of Pharmacology and Chemical Biology,Shanghai Jiao Tong University School of Medicine 3.中华科技大学 4.中国科学院化学研究所 5.Department of Chemistry,Tsinghua University 6.中国科学院上海药物研究所 7.College of Chemistry and Molecular Engineering,Peking University |
| 推荐引用方式 GB/T 7714 | Chu Wang,Peng Zou,Caiguang Yang,et al. Dynamic modifications of biomacromolecules:mechanism and chemical interventions[J]. 中国科学:生命科学英文版,2019,62.0(011):1459. |
| APA | Chu Wang.,Peng Zou.,Caiguang Yang.,Lei Liu.,Liang Cheng.,...&Peng RChen.(2019).Dynamic modifications of biomacromolecules:mechanism and chemical interventions.中国科学:生命科学英文版,62.0(011),1459. |
| MLA | Chu Wang,et al."Dynamic modifications of biomacromolecules:mechanism and chemical interventions".中国科学:生命科学英文版 62.0.011(2019):1459. |
入库方式： OAI收割
来源：上海药物研究所
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