Protective effects of Shengmai San and its three fractions on cerebral ischemia-reperfusion injury
文献类型：期刊论文
| 作者 | Li LaiHong; Wang JunSong; Kong LingYi |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2013 |
| 卷号 | 11期号:3页码:222 |
| 关键词 | NITRIC-OXIDE SYNTHASE ARTERY OCCLUSION OXIDATIVE DAMAGE FREE-RADICALS BRAIN-INJURY TNF-ALPHA MICE RAT ANTIOXIDANT MACROPHAGES Shengmai San Common carotid artery occlusion (CCAO) Antioxidant Anti-inflammatory |
| ISSN号 | 1672-3651 |
| 英文摘要 | AIM: To investigate the antioxidant and anti-inflammatory effects of Shengmai San (SMS) and its ethyl acetate extract (SEa), n-butanol extract (SBu), and aqueous extract (SWe), and clarify the material base of SMS and the roles played by its fractions. METHODS: A mouse model of transient forebrain ischemia/reperfusion (I/R) by means of common carotid artery occlusion (CCAO) was used to investigate the effects of SMS and its three fractions. Histopathological damage, blood-brain barrier disruption, and antioxidant and inflammation-related parameters, including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), myeloperoxidase (MPO), nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha) were measured. The chemical constituents of each fraction were identified by LC-MS. RESULTS: Eighteen lignans in SEa, and thirteen steroidal glycosides and ginsenosides in SBu were determined. SMS significantly inhibited I/R induced formation of histological injury and cerebral MPO activity. SMS showed the strongest antioxidant and anti-inflammatory effects against the I/R-caused injuries. SEa showed higher antioxidant activity than the other two fractions and SBu has a slightly stronger inhibition on the productions of NO and TNF-alpha. CONCLUSION: SMS as a whole had the most effective protection against cerebral I/R-caused injuries compared with its fractions, which inferred that it contains different groups of compounds that contribute together to its protective effect. |
| 资助项目 | [National Natural Science Foundation of China] ; [Program for New Century Excellent Talents in University] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294288]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Li LaiHong,Wang JunSong,Kong LingYi. Protective effects of Shengmai San and its three fractions on cerebral ischemia-reperfusion injury[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2013,11(3):222. |
| APA | Li LaiHong,Wang JunSong,&Kong LingYi.(2013).Protective effects of Shengmai San and its three fractions on cerebral ischemia-reperfusion injury.CHINESE JOURNAL OF NATURAL MEDICINES,11(3),222. |
| MLA | Li LaiHong,et al."Protective effects of Shengmai San and its three fractions on cerebral ischemia-reperfusion injury".CHINESE JOURNAL OF NATURAL MEDICINES 11.3(2013):222. |
入库方式： OAI收割
来源：上海药物研究所
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