Design and synthesis of novel triazole derivatives containing g-lactam as potential antifungal agents
文献类型：期刊论文
| 作者 | Xu Yuanyuan2; Qian Anran2; Cao Xufeng2; Ling Chenyu2; Cao Yongbing1; Wang Ruilian1; Li Yisu2; Yang Yushe2
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| 刊名 | Chinese Chemical Letters
 |
| 出版日期 | 2016 |
| 卷号 | 27期号:5页码:703 |
| ISSN号 | 1001-8417 |
| 关键词 | Synthesis Triazole g-Lactam Antifungal activity |
| 英文摘要 | A series of novel triazole derivatives containing g-lactam were designed and synthesized, and their structures were confirmed by ~1H NMR, ~(13)C NMR and HRMS. The in vitro antifungal activities of the target compounds were evaluated. The results showed that all of the compounds exhibited stronger activity against the six clinically important fungi tested than fluconazole. 3D and 3E showed comparative activity against the fungi tested except for Candida glabrata and Aspergillus fumigatus as voriconazole. In addition, the docking model for 2A and CYP51 was investigated. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294557]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.第二军医大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Xu Yuanyuan,Qian Anran,Cao Xufeng,et al. Design and synthesis of novel triazole derivatives containing g-lactam as potential antifungal agents[J]. Chinese Chemical Letters,2016,27(5):703. |
| APA | Xu Yuanyuan.,Qian Anran.,Cao Xufeng.,Ling Chenyu.,Cao Yongbing.,...&Yang Yushe.(2016).Design and synthesis of novel triazole derivatives containing g-lactam as potential antifungal agents.Chinese Chemical Letters,27(5),703. |
| MLA | Xu Yuanyuan,et al."Design and synthesis of novel triazole derivatives containing g-lactam as potential antifungal agents".Chinese Chemical Letters 27.5(2016):703. |
入库方式： OAI收割
来源：上海药物研究所
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